Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightCompared with surgical metastasectomy, similar overallsurvival rates could be achieved in our patient collective after iBT application.
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Özet
PURPOSEWe aimed to evaluate the safety and effectiveness of image-guided high-dose rate interstitialbrachytherapy (iBT) for the treatment of patients with hepatic, lymphatic, and pancreatic metastases originating from gastric cancer, an entity rarely surgically treatable with curative intent.METHODSTwelve patients with a cumulative number of 36 metastases (29 liver, 2 pancreatic, 5 lymph node)from histologically proven gastric adenocarcinoma received iBT between 2010 and 2016 andwere retrospectively analyzed. Every patient underwent palliative chemotherapy prior to iBT.The iBT procedure employs a temporarily, intratumorally placed iridium-192 source in a singlefraction with the goal of tumor cell eradication. Effectiveness was assessed clinically and by radiologic imaging every three months.RESULTSLocal tumor control was achieved in 32 of all treated metastases (89%). Four lesions showed a local recurrence after 7 months. Lesion sizes varied from 9 to 102 mm with a median of 20 mm. Themedian progression-free survival was 6.6 months (range, 1.8–46.8 months). The median overallsurvival was 11.4 months (range, 5–47 months). One patient suffered a major complication following iBT, hepatic hematoma and abscess (Common Terminology Criteria for Adverse Eventsgrade 3), successfully dealt with by transcutaneous drainage.CONCLUSIONiBT is an overall safe procedure, which facilitates high rates of local tumor control in treatmentof metastatic gastric adenocarcinoma. Compared with surgical metastasectomy, similar overallsurvival rates could be achieved in our patient collective after iBT application.