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Dergiler / Gülhane Tıp Dergisi / 2021 / Cilt: 63 - Sayı: 2

Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma

Kadir CANOĞLU
Oğuzhan OKUTAN
Dilaver TAŞ
İsmail YILMAZ
Soner YEŞİLBAŞ
Tayfun ÇALIŞKAN
Ayşe Filiz ARPAÇAĞ KOŞAR
Zafer KARTALOĞLU
Ömer AYTEN
Yasin UYAR
Sayfa
104–109
DOI
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Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aims: Asthma is a chronic inflammatory disease of the airways.
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Temel Bulgular & Veri:The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma.
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Sonuç & Katkı:Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aims: Asthma is a chronic inflammatory disease of the airways. The aim of the study was to investigate the association between serum interleukin (IL)-33 level and IL-33 gene rs1342326, rs1929992 and rs3939286 polymorphisms in patients with asthma. Methods: Ninety patients aged 18 years and older, who were diagnosed with asthma, and 90 healthy control subjects were included in the study. Serum IL-33 levels were measured by enzyme-linked immunosorbent assay; and IL-33 gene polymorphisms were studied by realtime polymerase chain reaction. Results: IL-33 level was higher in patients with asthma (4.16±0.88 pg/mL) compared to the control subjects (1.28±0.37 pg/mL) (p<0.001). The frequencies of AA, CC and AC alleles for the rs1342326 polymorphism were 52 (57.8%), 5 (5.6%) and 33 (36.7%) in the patient group, and 53 (58.9%), 7 (7.8%) and 30 (33.3%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs1929992 polymorphism were 17 (18.9%), 31 (34.4%), and 42 (46.7%) in the patient group and 13 (14.4%), 41 (45.6%), and 36 (40%) in the control group, respectively. The frequencies of CC, TT and CT alleles for the rs3939286 polymorphism were 46 (51.1%), 7 (7.8%), and 37 (41.1%) in the patient group and 44 (48.9%), 9 (10%), and 37 (41.1%) in the control group, respectively. There was no statistically significant difference between the groups in terms of IL-33 gene polymorphisms (rs1342326, rs1929992 and rs3939286) (p=0.784, p=0.304, p=0.863, respectively). Conclusions: The current study showed increased serum IL-33 levels in patients with asthma compared to healthy controls but gene polymorphism studies did not show any significant difference.

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Bu Makaleye Atıf Yap

CANOĞLU, K., OKUTAN, O., TAŞ, D., YILMAZ, İ., YEŞİLBAŞ, S., ÇALIŞKAN, T., KOŞAR, A. F. A., KARTALOĞLU, Z., AYTEN, Ö., UYAR, Y. (2021). Evaluation of serum interleukin-33 and gene polymorphisms in patients with bronchial asthma. Gülhane Tıp Dergisi, Cilt: 63 - Sayı: 2, 104–109. https://ajindex.com/articles/347981

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