Dergiler / Haseki Tıp Bülteni / 2021 / Cilt: 59 - Sayı: 3

Evaluation of Relationship Between Tp-E Interval Values and QT Dispersion in Electrocardiogram in Children With B12 Vitamin Deficiency

Sayfa
203–209
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Tp-e/QT and Tp-e/QTc ratios in the patient groups were statistically significantly higher than the ones inthe control group (p<0.05).Conclusion: Repolarization differences in B12 deficient children when compared to those of healthy children, might reflect subclinicalsymptoms.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: B12 vitamin deficiency may cause cardiac autonomic dysfunction, heart rate variability, endothelial dysfunction and subclinicalatherosclerosis, a significant degree of reduction in heart ejection fraction and deformation of the left ventricular myocardium.
📊
Temel Bulgular & Veri:Weaimed to investigate the effect of B12 deficiency in children on cardiac electrical activity by comparing the Tp-e and QT dispersion valuesbetween healthy children and children with B12 deficiency.Methods: The demographic data, laboratory results electrocardiography and echocardiography results of isolated B12 patients (n=64)with vitamin B12 deficiency and control group (n=64) included in the study between 15.3.2020 and 15.06.2020 were prospectivelyrecorded and comparatively analyzed.Results: A total of 128 patients included in the study.
💡
Sonuç & Katkı:Tp-e/QT and Tp-e/QTc ratios in the patient groups were statistically significantly higher than the ones inthe control group (p<0.05).Conclusion: Repolarization differences in B12 deficient children when compared to those of healthy children, might reflect subclinicalsymptoms.
🔬Tür:Araştırma Makalesi
📍Kapsam:2020 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: B12 vitamin deficiency may cause cardiac autonomic dysfunction, heart rate variability, endothelial dysfunction and subclinicalatherosclerosis, a significant degree of reduction in heart ejection fraction and deformation of the left ventricular myocardium. Weaimed to investigate the effect of B12 deficiency in children on cardiac electrical activity by comparing the Tp-e and QT dispersion valuesbetween healthy children and children with B12 deficiency.Methods: The demographic data, laboratory results electrocardiography and echocardiography results of isolated B12 patients (n=64)with vitamin B12 deficiency and control group (n=64) included in the study between 15.3.2020 and 15.06.2020 were prospectivelyrecorded and comparatively analyzed.Results: A total of 128 patients included in the study. Corrected QT (QTc) value and Tp-e interval, were statistically significantly higherin the patient group (p<0.05). Tp-e/QT and Tp-e/QTc ratios in the patient groups were statistically significantly higher than the ones inthe control group (p<0.05).Conclusion: Repolarization differences in B12 deficient children when compared to those of healthy children, might reflect subclinicalsymptoms.

🔖

Bu Makaleye Atıf Yap

SOLAK, N., YOLCU, C., ELEVLİ, M., ŞAHİN, K. (2021). Evaluation of Relationship Between Tp-E Interval Values and QT Dispersion in Electrocardiogram in Children With B12 Vitamin Deficiency. Haseki Tıp Bülteni, Cilt: 59 - Sayı: 3, 203–209. https://ajindex.com/articles/347934

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Celik SF, Celik E. Subclinical atherosclerosis and impaired cardiac autonomic control in pediatric patients with Vitamin B12 deficiency. Niger J Clin Pract 2018;21:1012-6
  2. Sucharita S, Thomas T, Sowmya S, Krishnamachari S, Kurpad AV, Vaz M. Subclinical Vitamin B12 Deficiency and Heart Rate Variability Across Life Cycle. Curr Aging Sci 2016;9:217-23
  3. Castro-Torres Y, Carmona-Puerta R, Katholi RE. Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice. World J Clin Cases 2015;3:705-20
  4. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008;41:567-74
  5. Sucharita S, Sowmya S, Thomas T, Kurpad AV, Vaz M. Plasma vitamin B12, methylmalonic acid and heart rate variability in healthy young Indian adults. Int J Vitam Nutr Res 2013;83:147-53
  6. Sadeghian S, Fallahi F, Salarifar M, et al. Homocysteine, vitamin B12 and folate levels in premature coronary artery disease. BMC Cardiovasc Disord 2006;6:38
  7. Kaya Z, Bicer A, Yalcin F, et al. Impaired global and segmental myocardial deformation assessed by two-dimensional speckle tracking echocardiography in patients with vitamin B12 deficiency. Cardiol J 2014;21:60-6
  8. Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie 2013;95:1033-40
  9. Herzlich BC, Lichstein E, Schulhoff N, et al. Relationship among homocyst(e)ine, vitamin B-12 and cardiac disease in the elderly: association between vitamin B-12 deficiency and decreased left ventricular ejection fraction. J Nutr 1996;126:1249-53
  10. Beitzke M, Pfister P, Fortin J, Skrabal F. Autonomic dysfunction and hemodynamics in vitamin B12 deficiency. Auton Neurosci 2002;97:45-54
  11. Sucharita S, Dwarkanath P, Thomas T, Srinivasan K, Kurpad AV, Vaz M. Low maternal vitamin B12 status during pregnancy is associated with reduced heart rate variability indices in young children. Matern Child Nutr 2014;10:226-33
  12. Öner T, Guven B, Tavli V, Mese T, Yilmazer MM, Demirpence S. Postural orthostatic tachycardia syndrome (POTS) and vitamin B12 deficiency in adolescents. Pediatrics 2014;133:138-42
  13. Fresko I, Hamuryudan V, Demir M, et al. Intestinal permeability in Behçet’s syndrome. Ann Rheum Dis 2001;60:65-6. 14. an de Lagemaat EE, de Groot LCPGM, van den Heuvel EGHM. Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. Nutri