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Dergiler / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2021 / Cilt: 27 - Sayı: 2

Protective Eff ects of Chitosan and Chitosan Oligosaccharide on Sodium Fluoride-Induced Testicular Damage in Male Rats: A Stereological and Histopathological Study

Kitosan ve Kitosan Oligosakkaridin Erkek Sıçanlarda Sodyum Florür Kaynaklı Testis Hasarı Üzerindeki Koruyucu Etkileri: Stereolojik ve Histopatolojik Bir Çalışma

Fikret ALTINDAĞ
Uğur ÖZDEK
Sayfa
183–189
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

C and COS can have cytoprotective eff ects against testis damage

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Amaç & Hipotez:The aim of the present study was to investigate the potential protective eff ects of Chitosan (C) and Chitosan Oligosaccharide (COS) on sodium fl uoride (NaF) induced testicular damage.
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Temel Bulgular & Veri:Forty-two male Wistar rats were separated into six groups (n=7).
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Sonuç & Katkı:C and COS can have cytoprotective eff ects against testis damage
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

The aim of the present study was to investigate the potential protective eff ects of Chitosan (C) and Chitosan Oligosaccharide (COS) on sodium fl uoride (NaF) induced testicular damage. Forty-two male Wistar rats were separated into six groups (n=7). The Control group was given drinking water without Fluoride. NaF group was given NaF (100 mg/L) in their drinking water. NaF+C group was given NaF (100 mg/L) and C (250 mg/kg/day). NaF+COS group was given NaF (100 mg/L) and COS (250 mg/kg/day). C group was given C (250 mg/kg/day). COS group was given COS (250 mg/kg/day). Rats were given C and COS by gastric gavage. As a result, the total number of spermatogonia, Leydig cells, the total volume of the testis, the total volume of germinal epithelium, the total volume of seminiferous tubules, the total length of seminiferous tubules, and the height of germinal epithelium significantly decreased in the NaF group compared to the control group (P<0.05). These parameters significantly increased in the NaF + C and NaF + COS groups compared to the NaF group (P<0.05). Also, GSH and CAT significantly decreased, while MDA significantly increased in the NaF group. C and COS alleviate these changes. These findings indicate that NaF can cause testis damage. C and COS can have cytoprotective eff ects against testis damage

Abstract

Bu çalışmanın amacı, Kitosan (K) ve Kitosan Oligosakkarit (KOS) sodyum fl orür (NaF) kaynaklı testis hasarı üzerindeki potansiyel koruyucu etkilerini araştırmaktır. Kırk iki erkek Wistar sıçanı altı gruba ayrıldı (n=7). Kontrol grubuna fl orsuz içme suyu verildi. NaF grubuna içme suyunda NaF (100 mg/L) verildi. NaF+K grubuna NaF (100 mg/L) ve K (250 mg/kg/gün) verildi. NaF + KOS grubuna NaF (100 mg/L) ve KOS (250 mg/ kg/gün) verildi. K grubuna K (250 mg/kg/gün) verildi. KOS grubuna KOS verildi (250 mg/kg/gün). Sıçanlara gastrik gavaj ile K ve KOS verildi. NaF grubunda, toplam spermatogonyum sayısı, Leydig hücresi sayısı, toplam testis hacmi, toplam germinal epitel hacmi, toplam seminifer tübül hacmi, seminifer tübüllerin toplam uzunluğu ve germinal epitel yüksekliği kontrol grubuna göre anlamlı olarak azalmıştır (P<0.05). Bu parametreler NaF + K ve NaF + KOS gruplarında NaF grubu ile karşılaştırıldığında istatistiksel açıdan önemli (P<0.05) biçimde artmıştır. Ayrıca NaF grubunda GSH ve CAT önemli derecede (P<0.05) azalırken, MDA önemli biçimde artmıştır. K ve KOS bu değişiklikleri hafifl ettiği gözlenmiştir. Bu bulgular, verilen dozdaki NaF’nin testis hasarına neden olabileceğini, K ve KOS’un sitoprotektif etkilerinin olabileceğini göstermektedir.

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Bu Makaleye Atıf Yap

ALTINDAĞ, F., ÖZDEK, U. (2021). Protective Eff ects of Chitosan and Chitosan Oligosaccharide on Sodium Fluoride-Induced Testicular Damage in Male Rats: A Stereological and Histopathological Study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 27 - Sayı: 2, 183–189. https://ajindex.com/articles/344080

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