Effect of induction agents on the antioxidative activity of desflurane in dogs

Amaç & Hipotez:The objective of this study was to determine the effects of different induction agents on the antioxidative activity of desflurane in dogs.

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Temel Bulgular & Veri:Sixteen healthy male crossbreed dogs, aged between 1 and 2 years and weighing between 16 and 22 kg were equally divided into two groups.

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Sonuç & Katkı:Therefore, it is possible that induction agents play a significant rol on the antioxidative effects of desflurane anaesthesia.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:antioksidanlar · süperoksit dismutaz · enzimler

Özet

The objective of this study was to determine the effects of different induction agents on the antioxidative activity of desflurane in dogs. Sixteen healthy male crossbreed dogs, aged between 1 and 2 years and weighing between 16 and 22 kg were equally divided into two groups. Anaesthetic protocols were designed as midazolam + thiopental + desflurane (Thio-Des group) or midazolam + ketamine + desflurane (Ket-Des group). Anaesthesia was induced with 0.3 mg kg-1 midazolam + 10 mg kg-1 thiopental or 0.3 mg kg-1 midazolam + 10 mg kg-1 ketamine hydrochloride combinations intraveneously. Anaesthesia maintenance was continued for 70 min(s) with 7-8% desflurane. Blood catalase, superoxide dismutase and hemoglobin activities were measured at control, anaesthesia induction, during the desflurane anaesthesia, one hour after anaesthesia and 24 hours after anaesthesia. In conclusion, thiopental administration in the anaesthesia induction increased superoxide dismutase activity (p 0.05). Therefore, it is possible that induction agents play a significant rol on the antioxidative effects of desflurane anaesthesia.

Abstract

Bu çalışmanın amacı köpeklerde desfluranın antioksidatif etkisi üzerinde farklı indüksiyon ajanlarının etkisini değerlendirmekti. Çalışmada 1-2 yaş ve 16-22 kg ağırlığında 16 melez sağlıklı erkek köpek iki eşit gruba bölündü. Anestezik protokoller midazolam + thiopental + desfluran (Thio-Des grup) veya midazolam + ketamine + desfluran (Ket-Des grup) olarak tasarlandı. Anestezi indüksiyonu intravenöz olarak 0.3 mg kg-1 midazolam + 10 mg kg-1 thiopental veya 0.3 mg kg-1 midazolam + 10 mg kg-1 ketamine hydrochloride kombinasyonu ile başarıldı. Anestezi idamesi 70 dakika % 7-8 desfluran ile sağlandı. Kan katalaz, süperoxit dismutaz ve hemoglobin aktiviteleri kontrol, anestezi indüksiyonu, desfluran anestezisi sırasında, anesteziden 1 ve 24 saat sonra ölçüldü. Sonuç olarak, anestezi indüksiyonunda thiopental verilmesi desfluran anestezisi sırasında süperoxit dismutaz aktivitesini (p<0.05), ketamine verilmesi ise katalaz (p<0.05) ve hemoglobin (p<0.01) aktivitelerini arttırdı. Fakat bu enzimler eşzamanlı olarak anesteziden 24 saat sonra her iki grupta da azaldı (p>0.05). Bu nedenle desfluranın antioksidatif etkisinde indüksiyon ajanlarının önemli rol oynadığı söylenebilir.

Anahtar kelimeler

antioksidanlar süperoksit dismutaz enzimler katalaz tiyopental ketamin köpek anestetikler antioxidants superoxide dismutase enzymes catalase thiopental ketamine dogs anaesthetics

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Bu Makaleye Atıf Yap

ALTUĞ, M. E., GÖNENCİ, R., YARSAN, E., ÖZTÜRK, A. (2008). Effect of induction agents on the antioxidative activity of desflurane in dogs. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 19 - Sayı: 1, 29–33. https://ajindex.com/articles/339878

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Kaynakça (13)

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