Isolation and identification of Two new cyclic amino acids from the seeds of Zizyphus spina-christi L. (Willd) by means of 1H-NMR-13C-NMR-HSQC-HMBC and GC-MS
The two compounds were identified by means of 1H-NMR-13C-NMR-HSQC-HMBC and GC-MS as 4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (less polar and major compound) and 4-hydroxy-4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (more polar and minor compound) of the ratio 4:3.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:In this study we isolate two new cyclic amino acids from the seeds of Zizyphus spina-christi L. (Willd ) 70% methanolic extract.
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Temel Bulgular & Veri:In this study we isolate two new cyclic amino acids from the seeds of Zizyphus spina-christi L. (Willd ) 70% methanolic extract.
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Sonuç & Katkı:The two compounds were identified by means of 1H-NMR-13C-NMR-HSQC-HMBC and GC-MS as 4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (less polar and major compound) and 4-hydroxy-4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (more polar and minor compound) of the ratio 4:3.
In this study we isolate two new cyclic amino acids from the seeds of Zizyphus spina-christi L. (Willd ) 70% methanolic extract. The two compounds were identified by means of 1H-NMR-13C-NMR-HSQC-HMBC and GC-MS as 4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (less polar and major compound) and 4-hydroxy-4-hydroxymethyl-1-methyl pyrrolidine-2-carboxylic acid (more polar and minor compound) of the ratio 4:3.
SAİD, A., HUEFNER, A., TABLE, E. S. A., FAWZY, G. (2010). Isolation and identification of Two new cyclic amino acids from the seeds of Zizyphus spina-christi L. (Willd) by means of 1H-NMR-13C-NMR-HSQC-HMBC and GC-MS. European Journal of Biology, Cilt: 69 - Sayı: 2, 77–85. https://ajindex.com/articles/33317
M. Abu-Zarga, S. Sabri and A AL-Aboudi, (1995) "New cyclopeptide alkaloids from Zizyphus lotus", Journal of Natural Production, 58, pp. 504-511. Adzu et al., 2001
B. Adzu, S. Amos, C Wambebe and K Gamaniel, (2001) "Antinociceptive activity of Zizyphusspinachristi root bark extract", Fitoterapia 72, pp. 344-350. Bm'boni et al., 1994
L. Barboni, P. Gariboldi, E. Torregiani and L. Verotta, (1994) "Cyclopeptide alkaloid from Zizyplzus 11111cronata", Phytochemistry 35 pp. 15791583. Borgi et al., 2007
W. Borgi, K Ghedira and N. Chouchane, (2007), " Anti-inflammatory and analgesic activities of Zizyphus lotus root barks", Fitoterapia 78 pp. 16-19. Cheng et al., 2000
G. Cheng, Y. Bai, Y Zhao, J. Tao, Y Liu, G. Tu, L. Ma, N. Liao and X. Xu, (2000), "Flavonoids from Zizyphus jujuba Mill var. Spinosa", Tetrahedron 56 pp. 8915-8920.
Chopra R.N., Nayar S.L. and Chopra I.C, (1956): "Glossary of Indian Medicinal Plants", 261, New Delhi: CSIR. Dalziel lM., (1937): "The Useful Plants of West Tropical Africa". p.300, The Crown Agent for Colonies, London. Duke J.A, (1985): "CRC Handbook of Medicinal Herbs". p.516: CRC Press Inc. Florida,USA Ghazanfar S.A, (1994),
Handbook of arabian medicinal plants, CRC Press, Boca Raton p.182. Han B.H. and Park M.H., (1986), Folk medicine: The art and science, The American Chemical Society, Washington, p.206. Han et al., 1990
B.H. Han, M.H. Park and YN. Han (1990)" "Cyclic peptide and peptide alkaloids from seeds of Zizyphus vulgaris," Phytochemistry 29 pp. 3315-3319. Higuchi et al., 1984
R. Higuchi, S. Kubota, T. Komori, T. Kawasaki, Y.B. Pardey, J.P. Singh and AR. Shah(1984)" "Triterpenoid saponins from the bark of Zizyphus joazeiro", Phytochemistry 23 pp. 25972600. Hutchens AR., (1973): Indian hierology of North America. Ontario, Canada: Mero. Ikram M,. Ogihara Y and Yamasaki K (1981), Structure of a new saponin from Zizyphus vulgaris, Journal of Natural Products 44 (1), pp. 91-93. Kirtikar K.R. and Basu B.D., (1984),
Indian medicinal plants, Springer, Berlin (1984), p. 593. Lee S.S., Lin B.P. and Liu KC, (1996): " Three Triterpene Esters from Zizyphus jujuba" Phytochemistry; 43 (4): 847-851.
Nawwar M.M., Ishak M.S., Michael R.N. and Buddrus l, (1984): Leaf flavonoids of Zizyphus spina-christi, Phytochemistry 23 (9) (1984), pp. 2110-2111. Nunes et al., 1987
P.R. Nunes, L.C Marinho, M.L.R.L. Nunes and E.O. Soares(1987)" "Antipyretic activity of an aqueous extract of Zizyphus joazeiro Mali (Rhamnaceae) ", Bra