Dergiler / Ulusal Travma ve Acil Cerrahi Dergisi / 2019 / Cilt: 25 - Sayı: 6

Evaluation of current therapeutic approach to obstructive and perforated colorectal cancers

Obstrükte ve perforasyonlu kolorektal kanser hastalarına güncel tedavi yaklaşımının değerlendirilmesi

Sayfa
589–596
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Our findings suggest that early detection and treatment of CRC with screening programs can be life-saving

📌 3 Maddede Bu Makale

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Amaç & Hipotez:BACKGROUND: Late diagnosis continues to be a significant problem in the treatment of colorectal cancer (CRC).
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Temel Bulgular & Veri:METHODS: Between 2012 and 2017, 612 patients underwent surgery for CRC.
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Sonuç & Katkı:Our findings suggest that early detection and treatment of CRC with screening programs can be life-saving
🔬Tür:Araştırma Makalesi
📍Kapsam:2012 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

BACKGROUND: Late diagnosis continues to be a significant problem in the treatment of colorectal cancer (CRC). Most cases require emergency surgical intervention due to acute intestinal obstruction or perforation. This retrospective study was formed from an assessment of the clinical presentation, treatment, early results, and survival of patients with CRC undergoing emergency surgery for acute obstruction or perforation. METHODS: Between 2012 and 2017, 612 patients underwent surgery for CRC. In all, 179 patients who required emergency treatment were retrospectively evaluated according to age, gender, significant comorbidities, physiological status, surgical indications, tumor location, tumor stage, perioperative blood transfusion rate, type of surgery, and the length of the operation and hospitalization. RESULTS: In total, 152 (85%) patients had a complete obstruction and 27 (15%) patients had a perforation. A major postoperative complication was identified nearly in half of the patients. The overall mortality rate was 12% (22 patients). Mortality was seen in 12% (18 patients) cases received surgery due to obstruction and in 15% (four patients) cases received surgery due to perforation. Perioperative blood transfusion and a high Acute Physiology and Chronic Health Evaluation II score were independent factors that predicted a major complication. Advanced age and perioperative blood transfusion were statistically independent prognostic factors for mortality. CONCLUSION: Consisted with the findings of studies in the literature, the results of this study also revealed a high perioperative morbidity and mortality rate in patients with CRC who required urgent surgery. Our findings suggest that early detection and treatment of CRC with screening programs can be life-saving

Abstract

AMAÇ: Kolorektal kanserin (KRK) tedavisinde tanıda gecikme önemli bir sorun olmaya devam etmektedir. Birçok olgu akut bağırsak obstrüksiyonu ya da perforasyonundan ötürü acil cerrahi müdehaleyi gerektirir. Bu geriye dönük çalışma akut obstrüksiyon ya da peforasyon için acil cerrahi müdehaleye maruz kalan KRK'li hastaların sağkalımı, erken ameliyat sonrası sonuçları, tedavileri ve klinik durumlarını değerlendirmeyi amaçlamıştır. GEREÇ VE YÖNTEM: 2012–2017 yılları arasında toplam 612 hasta KRK nedeniyle ameliyat edildi. Bu hastalar içinde acil müdehale gerektiren 179 hasta yaş, cinsiyet, komorbidite, fizyolojik durum, cerrahi endikasyon, tümör lokalizasyonu, tümör evresi, perioperatif kan transfüzyon oranı, cerrahi müdehale şekli ve hastanede kalma ve ameliyat geriye dönük olarak değerlendirildi. BULGULAR: Toplamda 152 (%85) hastada tam obstrüksiyon, 27 hastada (%15) perforasyon vardı. Majör ameliyat sonrası komplikasyon hastaların neredeyse yarısında gözlendi. Genel mortalite oranı %12 (22 hasta) idi. Obstrüksiyon nedeniyle ameliyat edilen hastaların %12'sinde (18 hasta), perforasyon nedeniyle ameliyat edilen hastaların ise %15'inde (4 hasta) mortalite gelişti. Peroperatuvar kan transfüzyonu ve yüksek ASA skoru majör komplikasyonu öngören bağımsız prognostik faktörler olarak tespit edilirken, ileri yaş ve peroperatuvar kan transfüzyonu mortaliteyi öngören bağımsız risk faktörü olarak bulundu. TARTIŞMA: Başka çalışmalarda da görüldüğü üzere, bizim yazımızda da acil cerrahi girişim gerektiren KRK hastalarında yüksek oranda peroperatuvar morbidite ve mortaliteye rastladık. Tarama programları yardımıyla erken tanı ve tedavi bu hastalıkta yaşam kurtarıcı rol oynamaktadır.

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Bu Makaleye Atıf Yap

KAYA, S., ŞEKER, A., ALTIN, Ö., ALTUNTAŞ, Y. E., KAPTANOĞLU, L., KEMENT, M., BİLDİK, N., KÜÇÜK, H. (2019). Evaluation of current therapeutic approach to obstructive and perforated colorectal cancers. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 25 - Sayı: 6, 589–596. https://ajindex.com/articles/324481

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Kaynakça (6)

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