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Dergiler / Ulusal Travma ve Acil Cerrahi Dergisi / 2016 / Cilt: 22 - Sayı: 6

Therapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injury

Çağrı KÖKOĞLU
EMRE DELEN
ALİ ARSLANTAŞ
Didem ARSLANTAŞ
Burcu KÖKOĞLU
ZÜHTÜ ÖZBEK
SEMA USLU
Ahmet Tolgay AKINCI
Sayfa
521–525
DOI
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CONCLUSION: It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.

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Amaç & Hipotez:BACKGROUND: This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI).METHODS: Thirty-five Sprague Dawley rats were distributed into 5 groups.
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Temel Bulgular & Veri:Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra.
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Sonuç & Katkı:CONCLUSION: It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.
🔬Tür:Araştırma Makalesi
📍Kapsam:2000 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

BACKGROUND: This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI).METHODS: Thirty-five Sprague Dawley rats were distributed into 5 groups. First group was used for normal biochemical values. Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra. Second group was designated solvent group and received 1 cc physiological serum after injury. Third group was medicated with intraperitoneal 2000 u/kg single dose erythropoietin after injury. Orogastric 2 mg/kg single dose tadalafil was administered to fourth group after injury. Fifth group did not receive any treatment and was used for biochemical values with injury. All subjects were sacrificed 48 hours after application. Malondialdehyde (MDA) and total antioxidant capacity (TAOC) values were evaluated using blood and tissue samples.RESULTS: Lowest serum and tissue MDA values were found in group with erythropoietin intake. While highest serum TAOC values of all groups were seen in tadalafil group, highest tissue TAOC values were observed in group given erythropoietin. CONCLUSION: It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.

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Bu Makaleye Atıf Yap

KÖKOĞLU, Ç., DELEN, E., ARSLANTAŞ, A., ARSLANTAŞ, D., KÖKOĞLU, B., ÖZBEK, Z., USLU, S., AKINCI, A. T. (2016). Therapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injury. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 22 - Sayı: 6, 521–525. https://ajindex.com/articles/323750

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Kaynakça (13)

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