Dergiler / Ulusal Travma ve Acil Cerrahi Dergisi / 2020 / Cilt: 26 - Sayı: 3

Comparison of thiol/disulphide homeostasis withmodified Alvarado and RIPASA scores in thediagnosis of acute appendicitis

Akut apandisit tanısında tiyol/disülfit homeostazının modifiye Alvarado ve RIPASA skorları ile karşılaştırılması

Sayfa
389–395
DOI
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The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were recorded to be significantly higher in the high-risk group according to the results of RIPASA (p=0.016, 0.003 and 0.001, respectively).CONCLUSION:Thiol/disulfide homeostasis parameters can be used with the modified Alvarado and RIPASA scoring systems in the diagnosis of acute appendicitis.

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Amaç & Hipotez:BACKGROUND:This study aims to investigate the role of thiol/disulfide homeostasis parameters in the diagnosis of acute ap-pendicitis and to determine whether it is beneficial to use these parameters in combination with the modified Alvarado and RIPASA scoring systems.METHODS:This study was prospectively carried out on 265 patients who presented to the emergency department with the com-plaint of right lower quadrant pain between 01.07.2017 and 31.12.2017, and met the inclusion criteria of this study.
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Temel Bulgular & Veri:The relationship between these parameters and the modified Alvarado and RIPASA scoring systems was analyzed.RESULTS:The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were found to be significantly higher in the appendicitis group (p<0.001).
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Sonuç & Katkı:The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were recorded to be significantly higher in the high-risk group according to the results of RIPASA (p=0.016, 0.003 and 0.001, respectively).CONCLUSION:Thiol/disulfide homeostasis parameters can be used with the modified Alvarado and RIPASA scoring systems in the diagnosis of acute appendicitis.
🔬Tür:Araştırma Makalesi
📍Kapsam:2017 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

BACKGROUND:This study aims to investigate the role of thiol/disulfide homeostasis parameters in the diagnosis of acute ap-pendicitis and to determine whether it is beneficial to use these parameters in combination with the modified Alvarado and RIPASA scoring systems.METHODS:This study was prospectively carried out on 265 patients who presented to the emergency department with the com-plaint of right lower quadrant pain between 01.07.2017 and 31.12.2017, and met the inclusion criteria of this study. Oxidative stress markers were evaluated on two groups. The relationship between these parameters and the modified Alvarado and RIPASA scoring systems was analyzed.RESULTS:The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were found to be significantly higher in the appendicitis group (p<0.001). The mean levels of native thiol, total thiol and native thiol/total thiol were significantly lower in the same group (p<0.001, 0.001 and 0.007, respectively). The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were recorded to be significantly higher in the high-risk group according to the results of RIPASA (p=0.016, 0.003 and 0.001, respectively).CONCLUSION:Thiol/disulfide homeostasis parameters can be used with the modified Alvarado and RIPASA scoring systems in the diagnosis of acute appendicitis.

Abstract

AMAÇ: Bu çalışma, akut apandisit tanısında tiyol/disülfit homeostaz parametrelerinin rolünü göstermeyi ve bu parametrelerin modifiye Alvarado ve RIPASA skorlama sistemleriyle birlikte kullanılmasının yararlı olup olmadığını belirlemeyi amaçlamaktadır.GEREÇ VE YÖNTEM: Bu çalışma, acil servise 01.07.2017 ve 31.12.2017 tarihleri arasında sağ alt kadran ağrısı şikayeti ile başvuran ve çalışmanın dahil edilme kriterlerini karşılayan 265 hastada ileriye yönelik olarak gerçekleştirildi. Oksidatif stres belirteçleri iki grupta değerlendirildi. Bu paramet-relerle modifiye Alvarado ve The Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) skorlama sistemleri arasındaki ilişki analiz edildi.BULGULAR: Apandisit grubunda ortalama disülfit, disülfit/native tiyol ve disülfit/total tiyol seviyeleri anlamlı olarak yüksek bulundu (p<0.001). Native tiyol, total tiyol ve native tiyol/total tiyol ortalamaları aynı grupta anlamlı olarak düşüktü (sırasıyla, p<0.001, 0.001 ve 0.007). Ortalama di-sülfid, disülfid/native tiyol ve disülfid/total tiyol seviyelerinin RIPASA sonuçlarına göre yüksek riskli grupta anlamlı olarak yüksek olduğu saptanmıştır (sırasıyla, p=0.016, 0.003 ve 0.001).TARTIŞMA: Tiyol/disülfit homeostaz parametreleri, akut apandisit tanısında modifiye Alvarado ve RIPASA skorlama sistemleriyle birlikte kullanı-labilir.

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Bu Makaleye Atıf Yap

GÖKHAN, S., AYDIN, İ. E., GÜNAYDIN, G. P., YILDIRIM, Ç., TANRIVERDİ, F., GÜRÜ, S., KAHRAMAN, A. F., EREL, Ö. (2020). Comparison of thiol/disulphide homeostasis withmodified Alvarado and RIPASA scores in thediagnosis of acute appendicitis. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 26 - Sayı: 3, 389–395. https://ajindex.com/articles/323482

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Kaynakça (13)

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