Dergiler / Ulusal Travma ve Acil Cerrahi Dergisi / 2020 / Cilt: 26 - Sayı: 3

Immediate versus delayed primary repair of the sciatic nerve in a nerve transaction model in rats

Sıçanlarda sinir transeksiyon modelinde siyatik sinirin acil ve gecikmeli primer onarımı

Sayfa
361–365
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, these parameters were significantly better in both repair groups than to be in the control group and significantly worse than to be in the sham-operated group.CONCLUSION:To delay the repair about one week did not affect the histological results and weight of the muscle that was inner-vated by the sectioned nerve comparing to be in the immediate repair in a sciatic nerve transaction model in rats.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:BACKGROUND:The debate continues concerning surgical timing in a peripheral nerve injury.
📊
Temel Bulgular & Veri:This study aims to evaluate the result of immediate versus delayed primary (after seven days) repair of peripheral nerve injury.METHODS:In this study, Wistar rats were divided into four groups as follows: The nerve was sharply transected in Group 1, 2 and 4.
💡
Sonuç & Katkı:However, these parameters were significantly better in both repair groups than to be in the control group and significantly worse than to be in the sham-operated group.CONCLUSION:To delay the repair about one week did not affect the histological results and weight of the muscle that was inner-vated by the sectioned nerve comparing to be in the immediate repair in a sciatic nerve transaction model in rats.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

BACKGROUND:The debate continues concerning surgical timing in a peripheral nerve injury. This study aims to evaluate the result of immediate versus delayed primary (after seven days) repair of peripheral nerve injury.METHODS:In this study, Wistar rats were divided into four groups as follows: The nerve was sharply transected in Group 1, 2 and 4. It was immediately sutured in Group 1 and sutured seven days later in Group 2, and it was not sutured in Group 4. In Group 3, the left sciatic nerve was only explored. Eight weeks later, tissue samples were extracted from the injured nerve area. Both gastrocnemius muscles were weighed. The nerve samples were examined for axon degeneration. Myelin vacuolization, axon irregularity, and edema/inflammation parameters were evaluated.RESULTS:There were not any significant differences in the score of axon degeneration and the weight of the gastrocnemius muscle between the immediate and delayed primary repair groups. However, these parameters were significantly better in both repair groups than to be in the control group and significantly worse than to be in the sham-operated group.CONCLUSION:To delay the repair about one week did not affect the histological results and weight of the muscle that was inner-vated by the sectioned nerve comparing to be in the immediate repair in a sciatic nerve transaction model in rats.

Abstract

AMAÇ: Periferik sinir yaralanmasında cerrahinin zamanlaması hala tartışmalıdır. Periferik sinir hasarının derhal ve gecikmiş primer (yedi gün sonra) onarımının sonuçları değerlendirildi.GEREÇ VE YÖNTEM: Wistar cinsi sıçanlar 4 gruba ayrıldı: Sinir keskin şekilde Grup 1, 2 ve 4’te kesildi. Grup 1’de hemen dikildi ve Grup 2’de yedi gün sonra dikildi ve Grup 4’te dikilmedi. Grup 3’te sol siyatik sinir sadece eksplore edildi. Sekiz hafta sonra, yaralanan sinir bölgesinden doku örnek-leri alındı. Her iki gastrocnemius kasları tartıldı. Sinir örnekleri akson dejenerasyonu açısından incelendi. Miyelin vakuolizasyonu, akson düzensizliği ve ödem/enflamasyon parametreleri değerlendirildi.BULGULAR: Acil ve gecikmiş primer onarım grupları arasında akson dejenerasyonu skoru ve gastrocnemius kasının ağırlığı açısından anlamlı fark yoktu. Bununla birlikte, bu parametreler her iki tamir grubunda da kontrol grubundan anlamlı derecede daha iyiydi ve sinir kesisi yapılmayan gruptan anlamlı derecede daha kötüydü.TARTIŞMA: Sıçanlarda siyatik sinir transeksiyon modelinde onarımın yaklaşık bir hafta geç yapılması acil onarım ile karşılaştırıldığında, kesilmiş sinirin uyardığı kasın histolojik sonuçlarını ve ağırlığını etkilememiştir.

🔖

Bu Makaleye Atıf Yap

TUFAN, A., KARAGÖZ, F. G., EREN, B., TAŞ, A., İŞLER, C., AKKALP, A. K., GÜLEÇ, İ., YAYLA, V. A., ÇABALAR, M. (2020). Immediate versus delayed primary repair of the sciatic nerve in a nerve transaction model in rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 26 - Sayı: 3, 361–365. https://ajindex.com/articles/323481

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Campbell WW. Evaluation and management of peripheral nerve injury. Clin Neurophysiol 2008;119:1951–65
  2. Dahlin LB. The role of timing in nerve reconstruction. Int Rev Neurobiol 2013;109:151–64
  3. Gezercan Y, Menekşe G, Ökten Aİ, Arslan A, Özsoy KM, Ateş T, et al. The Outcomes of Late Term Surgical Treatment of Penetrating Peripheral Nerve Injuries. Turk Neurosurg 2016;26:146−52
  4. Moore AM, Wagner IJ, Fox IK. Principles of nerve repair in complex wounds of the upper extremity. Semin Plast Surg 2015;29:40–7
  5. Sinha S, Khani M, Mansoori N, Midha R. Adult brachial plexus injuries: Surgical strategies and approaches. Neurol India 2016;64:289–96
  6. Nouraei MH, Hosseini A, Salek S, Nouraei F, Bina R. Median and ulnar nerve injuries; what causes different repair outcomes?. Adv Biomed Res 2015;4:215
  7. Saito H, Dahlin LB. Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair. BMC Neurosci. 2008;9:88
  8. Erakat MS, Chuang SK, Shanti RM, Ziccardi VB. Interval between injury and lingual nerve repair as a prognostic factor for success using type I collagen conduit. J Oral Maxillofac Surg 2013;71:833–8
  9. Jivan S, Kumar N, Wiberg M, Kay S. The influence of pre-surgical delay on functional outcome after reconstruction of brachial plexus injuries. J Plast Reconstr Aesthet Surg 2009;62:472–9
  10. Birch R, Raji AR. Repair of median and ulnar nerves. Primary suture is best. J Bone Joint Surg Br 1991;73:154–7
  11. Leclercq DC, Carlier AJ, Khuc T, Depierreux L, Lejeune GN. Improvement in the results in sixty-four ulnar nerve sections associated with arterial repair. J Hand Surg Am 1985;10:997–9
  12. Merle M, Amend P, Foucher G, Michon J. Plea for the primary microsurgical repair of peripheral nerve lesions. A comparative study of 150 injuries of the median or the ulnar nerve with a follow-up of more than 2 years. [Article in French] Chirurgie 1984;110:761–71
  13. Ruijs AC, Jaquet JB, Kalmijn S, Giele H, Hovius SE. Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast Reconstr Surg 2005;116:484–96
  14. Jonsson S, Wiberg R, McGrath AM, Novikov LN, Wiberg M, Novikova LN, et al. Effect of delayed peripheral nerve repair on nerve regeneration, Schwann cell function and target muscle recovery. PLoS One 2013;8:e56484
  15. Kuffler DP. An assessment of current techniques for inducing axon regeneration and neurological recovery following peripheral nerve trauma. P