Dergiler / Bakırköy Tıp Dergisi / 2021 / Cilt: 17 - Sayı: 1

Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism

Laktat Dehidrojenaz Albumin Oranının Pulmoner Emboli Tanısında Etkinliği

Sayfa
25–29
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in the diagnosis of PTE.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE).
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Temel Bulgular & Veri:Method: A total of 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden onset of dyspnea were enrolled in this single- center and retrospective study.
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Sonuç & Katkı:Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in the diagnosis of PTE.
🔬Tür:Araştırma Makalesi
📍Kapsam:2017 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE). Method: A total of 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden onset of dyspnea were enrolled in this single- center and retrospective study. Computed tomography pulmonary angiogram (CTPA) was performed to confirm pulmonary embolism. Results: LAR, neutrophil, monocyte, D-dimer, LDH values were significantly higher and albumin values were significantly lower in patients with pulmonary embolism compared to those without. Average age of 307 participants were 68.93 years. While 140 patients had confirmed PTE and 167 were without PTE. Linear regression analysis for LAR in the diagnosis of PTE, revealed a correlation coefficient as r=0.320 (p<0.001). Positive and negative predictive values for LAR in the diagnosisi of PTE were, 63.3% and 75.2%, respectively. In ROC analysis relation of LAR to PTE was found to be stronger than LDH and albumin alone. Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in the diagnosis of PTE.

Abstract

Amaç: Bu çalışmanın amacı laktat dehidrojenaz albumin oranının (LAR) pulmoner tromboemboli (PTE) tanısındaki etkinliğini incelemektir. Yöntem: Bu tek merkezli, retrospektif çalışmada, Ocak 2017 ile Mart 2020 tarihleri arasında acil servise göğüs ağrısı ve ani gelişen dispne nedeniyle başvuran ve PTE şüphesi ile PBTA yapılmış olan 307 hasta incelendi. Bulgular: PTE saptanan hastalarda, PTE saptanmayan hastalarla kıyaslandığında; LAR, nötrofil ve monosit sayımları, d-dimer ve LDH değerleri anlamlı olarak yüksek bulunurken, albumin değerleri anlamlı olarak daha düşük bulundu. Katılımcıların ortalama yaşı 68,93 olarak bulundu; 140 hastada PTE saptanırken 167'sinde PTE saptanmadı. LAR ile PTE arasındaki lineer regresyon analizinde korrelasyon katsayısı r=0,320. LAR için pozitif prediktif değer %63,3, negatif prediktif değer %75,2 olarak bulundu. Receiver operator characteristics (ROC) eğrisi incelemesinde LAR ile PTE arasındaki ilişki, tek başına LDH veya albumin testlerinden daha güçlü bulunmuştur. Sonuç: Basit ve her yerde yapılabilir bir test olarak LAR, PTE tanısında yeni bir parametre olarak kullanılabilir.

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Bu Makaleye Atıf Yap

ALANLI, R., KÜÇÜKAY, M. B., YALÇIN, K. S. (2021). Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi, Cilt: 17 - Sayı: 1, 25–29. https://ajindex.com/articles/309763

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