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Dergiler / Retina-Vitreus / 2019 / Cilt: 28 - Sayı: 3

Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis

Multiple Sklerozda Lamina Kribroza Tabakasının Araştırılması

Özkan KOCAMIŞ
Burç Esra ŞAHİN
Sayfa
296–301
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The LCT and RNFL thickness were thinner in MS patients than in the control group but there was no difference in terms of LCD values.

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Amaç & Hipotez:Purpose: We aimed to measure lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD) and retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) patients and compare the results with eyes of healthy subjects.
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Temel Bulgular & Veri:Results: Mean LCT values were 171.86±62.81 μm in the MS group and 230.1±66.84 μm in the control group.
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Sonuç & Katkı:The LCT and RNFL thickness were thinner in MS patients than in the control group but there was no difference in terms of LCD values.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Purpose: We aimed to measure lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD) and retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) patients and compare the results with eyes of healthy subjects. Materials and Methods: The eyes of multiple sclerosis patients were compared with the eyes of a healthy control group. A full ophthalmologic examination was conducted for both groups. Optic coherence tomography (OCT) was used to measure LCT, LCD, and RNFL thickness values. Correlation analysis was conducted between the Expanded Disability Status Scale (EDSS) score and disease duration of the MS patients and the LCT, LCD, and RNFL thicknesses. Results: Mean LCT values were 171.86±62.81 μm in the MS group and 230.1±66.84 μm in the control group. LCT was statistically significantly lower in the MS group than the control group (p<0.001). Mean LCD value was 300.9±100.5 μm in the MS group and 279.68±99.78 μm in the control group with no statistically signifi cant difference (p˃0.05). Mean RNFL thickness was 96 μm in MS group and 100 μm in the control group and was statistically signifi cantly lower in the MS group (p<0.05). A statistically signifi cantly moderate relationship was found between disease duration and EDSS score in the MS group with Spearman correlation analysis (r=0.468, p<0.01). A statistically signifi cantly moderate relationship was found between the RNFL thickness and both disease duration and EDSS score (r=-0.574, r=-0.601, respectively, p<0.001). Conclusion: The intraocular nerve fi ber layer was affected in multiple sclerosis patients. The LCT and RNFL thickness were thinner in MS patients than in the control group but there was no difference in terms of LCD values.

Abstract

Amaç: Multipl skleroz (MS) hastalarında lamina cribrosa kalınlığı (LKK), lamina cribrosa derinliği (LKD) ve retina sinir lifi tabakası (RSLT) kalınlığını ölçmeyi ve sağlıklı gözlerin sonuçları ile karşılaştırmayı amaçladık. Gereç ve Yöntemler: Multipl skleroz hastalarının gözleri sağlıklı kontrol grubunun gözleri ile karşılaştırıldı. Her iki grup için tam oftalmolojik muayene yapıldı. LKK, LKD ve RSLT kalınlık değerlerini ölçmek için optik koherens tomografi (OKT) kullanıldı. MS hastalarının Genişletilmiş Engellilik Durum Ölçeği (GEDÖ) skoru ve hastalık süresi ile LKK, LKD ve RSLT kalınlıkları arasında korelasyon analizi yapıldı. Bulgular: Ortalama LKK değerleri MS grubunda 171.86 ± 62.81 μm, kontrol grubunda 230.1 ± 66.84 μm idi. LKK MS grubunda kontrol grubundan istatistiksel olarak anlamlı derecede düşüktü (p <0.001). Ortalama LKD değeri MS grubunda 300.9 ± 100.5 μm, kontrol grubunda 279.68 ± 99.78 μm idi ve istatistiksel olarak anlamlı bir fark yoktu (p˃0.05). Ortalama RSLT kalınlığı MS grubunda 96 μm, kontrol grubunda 100 μm idi ve MS grubunda istatistiksel olarak anlamlı derecede düşüktü (p <0.05). Spearman korelasyon analizi ile MS grubunda hastalık süresi ile GEDÖ skoru arasında istatistiksel olarak anlamlı bir ilişki bulundu (r = 0.468, p <0.01). RSLT kalınlığı ile hem hastalık süresi hem de GEDÖ skoru arasında istatistiksel olarak anlamlı bir ilişki bulundu (r = -0.574, r = -0.601, sırasıyla, p <0.001). Sonuç: Göz içi sinir lifi tabakası multiple skleroz hastalarında etkilenmiştir. LKK ve RSLT kalınlığı MS hastalarında kontrol grubundan daha ince idi, ancak LKD değerleri açısından fark yoktu.

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Bu Makaleye Atıf Yap

KOCAMIŞ, Ö., ŞAHİN, B. E. (2019). Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus, Cilt: 28 - Sayı: 3, 296–301. https://ajindex.com/articles/304807

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