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Dergiler / Psychiatry and behavioral sciences (Online) / 2019 / Cilt: 9 - Sayı: 2

NPY Receptor Gene Polymorphisms in Anxiety Disorders

Funda YİĞİT YALÇIN
Abdullah BOLU
Hatice AKAR
Mehmet Sinan AYDIN
Ali Doruk KARAHAN
Sayfa
1–9
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies are needed on this topic and conducting studies with larger samples in the future will increase the validity of the results.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: In this study, we aimed to examine the NPY gene polymorphism in patients with panic disorder and generalized anxiety disorder and to determine the relationship between clinical variables and the NPY receptor gene polymorphisms.
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Temel Bulgular & Veri:A total of 11 single-nucleotide polymorphisms (SNPs) encoding the NPY Y1, Y2 and Y5 receptors were examined.
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Sonuç & Katkı:Further studies are needed on this topic and conducting studies with larger samples in the future will increase the validity of the results.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: In this study, we aimed to examine the NPY gene polymorphism in patients with panic disorder and generalized anxiety disorder and to determine the relationship between clinical variables and the NPY receptor gene polymorphisms. Methods: Twenty-nine patients with panic disorder (PD) and sixty-four patients with generalized anxiety disorder (GAD) were able to complete the study. A total of 11 single-nucleotide polymorphisms (SNPs) encoding the NPY Y1, Y2 and Y5 receptors were examined. Results: There was a genotype-based difference in six SNPs (namely, NPY Y1 (rs7687423, rs4691075), NPY Y2 (rs12507396, rs1047214, rs11728843), NPY Y5 (rs11946004)) of the patients in the anxiety disorder group when compared with the control group. The scores of the Beck-A Scale were higher in the patients that had CC genotype in the rs4691075 and rs1047214, and the ASI-3 scores were higher in the patients with CC genotype in the region of rs4691075. Additionally, the regression analysis demonstrated that having the GG genotype of rs7687423 increased the risk for anxiety disorder by 65.8 fold as compared to the AA genotype. Conclusions: Our findings supported an association between NPY and anxiety disorders. Furthermore, our results were consistent with the results of the previous studies delineating the role of NPY gene polymorphism in anxiety disorders in the literature. However, the small size of sample limits the generalization of the results. Further studies are needed on this topic and conducting studies with larger samples in the future will increase the validity of the results.

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Bu Makaleye Atıf Yap

YALÇIN, F. Y., BOLU, A., AKAR, H., AYDIN, M. S., KARAHAN, A. D. (2019). NPY Receptor Gene Polymorphisms in Anxiety Disorders. Psychiatry and behavioral sciences (Online), Cilt: 9 - Sayı: 2, 1–9. https://ajindex.com/articles/302819

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