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Dergiler / Retina-Vitreus / 2020 / Cilt: 29 - Sayı: 1

Evaluation of Total Oxidant Status, Total Antioxidant Capacity and Oxidative Stress Levels in Humor Aqueous of Diabetic Cataract Patients

Mevlüt YILMAZ
Bengü EKİNCİ KÖKTEKİR
Banu BOZKURT
Fikret AKYÜREK
Süleyman OKUDAN
Ali Rıza ÜNLÜ
Sayfa
25–29
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Increased oxidative stress may be a potential therapeutic target in the prevention and management of DRP.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Purpose: Diabetic retinopathy (DRP) is one of the most common complications of diabetes mellitus and various studies have demonstrated the role of increased oxidative stress due to hyperglycemia in its pathophysiology.
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Temel Bulgular & Veri:Materials and Methods: This prospective study included a total of 86 cataract patients: 31 healthy patients with senile cataract (Group 1), 19 diabetic patients without DRP (Group 2), 17 patients with nonproliferative DRP (Group 3), and 19 patients with proliferative DRP (Group 4).
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Sonuç & Katkı:Increased oxidative stress may be a potential therapeutic target in the prevention and management of DRP.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Purpose: Diabetic retinopathy (DRP) is one of the most common complications of diabetes mellitus and various studies have demonstrated the role of increased oxidative stress due to hyperglycemia in its pathophysiology. There are few studies in the literature examining total antioxidant capacity (TAC) and total oxidant status (TOS) in humor aqueous, and we were unable to fi nd any, which measured oxidative stress index (OSI). The aim of this study was to investigate whether TAC, TOS, and OSI in the aqueous humor changed according to DRP stage. Materials and Methods: This prospective study included a total of 86 cataract patients: 31 healthy patients with senile cataract (Group 1), 19 diabetic patients without DRP (Group 2), 17 patients with nonproliferative DRP (Group 3), and 19 patients with proliferative DRP (Group 4). Aqueous humor samples were obtained prior to cataract surgery. TAC, TOS, and OSI levels were measured spectrophotometrically and compared between the groups. Results: The analysis of TAC levels revealed that TAC levels were signifi cantly higher in the control group (Group 1) compared to DRP patients (Group 3 and 4, p=0.042 and p=0.02, respectively), while TOS and OSI levels were lower in Group 1 compared to all diabetic groups (Group 2, 3, and 4) (p<0.05). Conclusion: The fi ndings of increased TOS and OSI and decreased TAC levels in diabetic patients support the belief that oxidative stress might be an important etiologic factor in DRP. Increased oxidative stress may be a potential therapeutic target in the prevention and management of DRP.

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Bu Makaleye Atıf Yap

YILMAZ, M., KÖKTEKİR, B. E., BOZKURT, B., AKYÜREK, F., OKUDAN, S., ÜNLÜ, A. R. (2020). Evaluation of Total Oxidant Status, Total Antioxidant Capacity and Oxidative Stress Levels in Humor Aqueous of Diabetic Cataract Patients. Retina-Vitreus, Cilt: 29 - Sayı: 1, 25–29. https://ajindex.com/articles/298897

Kaynakça (16)

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