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Dergiler / Nöropsikiyatri Arşivi / 2018 / Cilt: 55 - Sayı: 1

Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study

Klinik İzole Sendromdan Multipl Skleroza Dönüşümü Temel Özelliklere Bağlı Olarak Öngörebilme

Bilge Piri CINAR
SERKAN ÖZAKBAŞ
Sayfa
15–21
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This information may be useful when considering treatment in CIS patients instead of waiting for conversion to MS.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Clinically isolated syndrome (CIS) is a clinical state that proceeds with inflammation and demyelination, suggestive of multiple sclerosis (MS) in the central nervous system in the absence of other alternative diagnoses.
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Temel Bulgular & Veri:A greater presence of oligoclonal bands in CSF was identified in the converted group (92.8%).
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Sonuç & Katkı:This information may be useful when considering treatment in CIS patients instead of waiting for conversion to MS.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Clinically isolated syndrome (CIS) is a clinical state that proceeds with inflammation and demyelination, suggestive of multiple sclerosis (MS) in the central nervous system in the absence of other alternative diagnoses. The purpose of this study was to determine in a prospective cohort, the predictor factors in conversion from CIS to MS on the basis of clinical, magnetic resonance (MR) imaging and cerebrospinal fluid (CSF) findings. Methods: Forty-one CIS patients were included in this study and followed up for at least two years. Results: Clinically, polysymptomatic or sensorial involvement, good prognostic factors and complete response to pulse therapy were found to be of prognostic value in conversion to MS. A greater presence of oligoclonal bands in CSF was identified in the converted group (92.8%). In terms of localization, presence of callosal lesion (71.4%), periventricular lesion (97.1%), Gd-enhanced lesion (48.6%), black hole (54.2%) and brainstem lesion (57.1%) was statistically significant in terms of conversion to MS. Conclusion: A carefully performed neurological assessment of symptoms and signs, and evaluation of lesions on MR combined with CSF findings are important for identifying the risk of conversion to MS. This information may be useful when considering treatment in CIS patients instead of waiting for conversion to MS.

Abstract

Amaç: Klinik izole sendrom, diğer alternatif tanıların yokluğunda multipl sklerozu (MS) düşündüren, santral sinir sisteminin inflamasyonu ve demiyelinizasyonu ile giden bir klinik durumdur. Bu çalışmada amacımız; klinik izole sendrom (KİS)’dan MS’e dönüşümü etkileyen öngörü etmenlerini klinik, MR görüntüleme ve beyin omurilik sıvısı (BOS) bulguları temelinde tanımlamaktır. Yöntem: Çalışmaya 41 KİS hastası alındı ve en az iki yıl süreyle takip edildi. Bulgular: Klinik olarak, polisemptomatik ve duyusal tutulum, iyi prognostik faktörler ve puls tedaviye tam yanıtın, MS’e dönüşümde prognostik değere sahip oldukları bulundu. BOS’ta oligoklonal bant (OKB) varlığı, MS’e dönen grupta daha fazla saptandı (%92,8). Beyinde lezyon lokalizasyonları incelendiğinde; korpus kallosum (%71,4), periventriküler lezyon (%97,1), beyin sapında lezyonu varlığı (%57,1), kara delik (%54,2) ve kontrast tutan lezyon varlığı (%48,6), MS’e dönüşümde anlamlı olarak değerlendirilmiştir. Sonuç: Hastanın semptom ve bulgularının nörolojik değerlendirmesinin dikkatlice yapılması ve MR’daki lezyonların ve BOS bulgularının değerlendirilmesi, KİS’ten MS’e dönüşüm riskinin tanımlanmasında oldukça önemlidir. Bu bilgiler, KİS hastalarında MS’e dönüşümü beklemeden tedavi planlanmasında kullanılabilir.

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Bu Makaleye Atıf Yap

CINAR, B. P., ÖZAKBAŞ, S. (2018). Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi, Cilt: 55 - Sayı: 1, 15–21. https://ajindex.com/articles/292203

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Kaynakça (3)

  1. Brex PA, O’Riordan JI, Miszkiel KA, Moseley IF, Thompson AJ, Plant GT, Miller DH. Multisequence MRI in clinically isolated syndromes and the early development of MS. Neurology 1999;53;1184–1190.
  2. Miller D, Barkhof F, Montalban X, Thompson A, Filippi M. Clinically isolated syndromes suggestive of multiple sclerosis, part I. natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol 2005;4:281–288. [CrossRef] Jacobi C, Hähnel S, Martinez-Torres F, Rieger S, Jüttler E, Heiland S, Jarius S, Meyding-Lamadè U, Storch-Hagenlocher B, Wildemann B. Prospective combined brain and spinal cord MRI in clinically isolated syndromes and possible early multiple sclerosis: impact on dissemination in space and time. Eur J Neurol 2008;15:1359–1364. [CrossRef] Noseworthy JH, Lucchinetti C, Rodrı´guez M, Weinshenker BG. Multiple sclerosis. N Engl J Med 2000;343:938–952. [CrossRef] Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 2000;343:898–904. [CrossRef] Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, Miller DH, Montalban X, Barkhof F, Bauer L, Jakobs P, Pohl C, Sandbrink R. Treatment with interferon beta-1b delays conversion to clinically definite MS in clinically isolated syndromes. Neurology 2006;67:1242–1249. [CrossRef] Miller D, Barkhof F, Montalban X, Thompson A, Filippi M. Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management. Lancet Neurol 2005;4:341–348. [CrossRef] McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121–127.
  3. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O’Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Critera”. Ann Neurol 2005;58:840–846. [CrossRef] Brex PA, Ciccarelli O, O’Riordan JI, Sailer M, Thompson AJ, Miller DH. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl