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Dergiler / Nöropsikiyatri Arşivi / 2021 / Cilt: 58 - Sayı: 1

Central Role of T Follicular Helper Cells in Myasthenia Gravis

Na WU
Erdem TÜZÜN
Yi CHENG
Li YAN
Yajun WU
Jie RAO
Hui HUANG
Siyu LI
Ling SHI
Xiaorong WU
Sayfa
68–72
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Thus, this article reviews the recently achieved research progress on the involvement of Tfh cells in MG immunopathogenesis and focuses on the role of Tfh cells and related-factors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation and antibody production in MG immune response.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Myasthenia gravis (gMG) is a critical autoimmune disease, which has a serious impact on the life and survival of patients.
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Temel Bulgular & Veri:Ocular Myasthenia Gravis (oMG) is often the initial manifestation of MG and has the potential to progress to gMG.
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Sonuç & Katkı:Thus, this article reviews the recently achieved research progress on the involvement of Tfh cells in MG immunopathogenesis and focuses on the role of Tfh cells and related-factors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation and antibody production in MG immune response.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Myasthenia gravis (gMG) is a critical autoimmune disease, which has a serious impact on the life and survival of patients. Ocular Myasthenia Gravis (oMG) is often the initial manifestation of MG and has the potential to progress to gMG. However, to date no distinct mechanism has been found to clarify the pathogenesis of conversion from oMG to gMG. Recent studies have shown that the development and clinical progression of MG is closely associated with the abnormal function of follicular helper T (Tfh) cells. Thus, this article reviews the recently achieved research progress on the involvement of Tfh cells in MG immunopathogenesis and focuses on the role of Tfh cells and related-factors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation and antibody production in MG immune response.

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Bu Makaleye Atıf Yap

WU, N., TÜZÜN, E., CHENG, Y., YAN, L., WU, Y., RAO, J., HUANG, H., LI, S., SHI, L., WU, X. (2021). Central Role of T Follicular Helper Cells in Myasthenia Gravis. Nöropsikiyatri Arşivi, Cilt: 58 - Sayı: 1, 68–72. https://ajindex.com/articles/292128

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Kaynakça (13)

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