KaydedilenlerDerginizi ekleyin

Dergiler / Marmara Medical Journal / 2002 / Cilt: 15 - Sayı: 1

Aprotinin improves Ca2+ - Mg2+ / ATPase levels in ischemia-reperfusion injury

C. Selim İSBİR
Rıza DOĞAN
Metin DEMİRCİN
İlhan PAŞAOĞLU
Sayfa
23–26
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Aprotinin protected the erythocyte membrane Ca2+-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. ,

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5' triphosphatase (Ca2+-Mg2VATP ase) levels.
📊
Temel Bulgular & Veri:Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each).
💡
Sonuç & Katkı:Conclusion: Aprotinin protected the erythocyte membrane Ca2+-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. ,
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Ca(2+) Mg(2+)-ATPaz · Aprotinin · Reperfüzyon hasarı

Abstract

Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5' triphosphatase (Ca2+-Mg2VATP ase) levels. Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each). Group A patients received full dose aprotinin (20 000 lU/kg as pretreatment followed by 7500 lU/kg for 6 hours) and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2VATP ase levels were measured. Results: Ca2+-Mg2+ /ATPase levels were protected in aprotinin group, 807.60+32.62 vs 634.28+22.91 (p<0.05) at post-operative 24th hour. (p<0.05). Conclusion: Aprotinin protected the erythocyte membrane Ca2+-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. ,

🔖

Bu Makaleye Atıf Yap

İSBİR, C. S., DOĞAN, R., DEMİRCİN, M., PAŞAOĞLU, İ. (2002). Aprotinin improves Ca2+ - Mg2+ / ATPase levels in ischemia-reperfusion injury. Marmara Medical Journal, Cilt: 15 - Sayı: 1, 23–26. https://ajindex.com/articles/284166

Kaynakça (15)

  1. Haherland OL, Me Conn RA. A rationale for the therapeutic action of Aprotinin. Fed Proceed 1979; 38: 2760-2767
  2. Lu H, Soria C, Commin PL, et al. Hemostasis in patients undergoing extracorporeal circulation; the effect of aprotinin (Trasylol). Thromb Haemost 1991; 66: 633-637
  3. Diaz PE, Fishbein MC, Davis MA, Askenazi J, Maroko PR. Effect of kallikrein inhibitor aprotinin on myocardial ischemic injury after coronary occlusion in the dog. Am J Cardiol 1977; 40: 541-549
  4. Wendel HP, Heller W, Michael J, et al. Lower cardiac troponin T levels in patients undergoing cardiopulmonary bypass and recieving high dose Aprotinin therapy indicate reduction of perioperative myocardiai damage. J Thorac Cardiovasc Surg 1995; 109: 1164-1172
  5. Lucchesi BR, Werns SW, Fantone JC. The role of the neutrophyl and free radicals in ischemic myocardiai injury. J Mol Cell Cardiol 1989;'21: 1241-1251
  6. Kaneko M, Matsumoto Y, Hayashi H, Kobayashi A, Yamazaki N. Oxygen free radicals and calcium homeostasis in the heart. Mol Cell Biochem 1994; 21: 1241- 1251
  7. Dick DA, Dick EG, Tusteson D. Inhibition of ATPase in sheep red cell membrane by oxidised glutathione. J Gen Physiol 1969; 54: 123-133
  8. Murphy E, Aitcon JF, florres CR, Lieberman M. Calcium elevation in cultured heart cells; its role in cell injury. Am J Fhysiol 1983; 245: 316-321
  9. Parr DR, Wimhurst JM, Harris EJ. Calcium induced damage of rat heart mitochondria. Cardiovasc Res 1975; 9: 366-372
  10. David-Dufilho M, Pernollet MG, LeQuan Sang H, et ah Active ria+ and Ca2+ transport, Na+-Ca2+ exchange and intracellular Tia+ and Ca2+ content in young spontaneously hypertensive rats. J Cardiovasc Pharmacol 1986; 8(suppl 8): 130-135
  11. Reading HW, İsbir T. Action of lithium on ATPase in transmitter release from rat iris. Biochem Pharmacol 1979; 28: 3471-3477
  12. Reading HW, isbir T. The role of cation activated ATPase in transmitter release from rat iris. Q J Exp Psychol 1979; 65: 105-116
  13. Atkinson A, Gatenby AD, Lowe AG. The determination of inorganic phosphate in biological systems. Biochem Biophys Ada 1973; 320: 195-204
  14. Lowry OH, Rosenburgh riJ, Fan AL, Randall RJ. Protein measurement with the fol in phenol reagent. J Biol Chem 1951; 193: 265- 275
  15. Haworth RA, Hunter DQ, Berkoff HA. Contracture in isolated adult rat heart cells. The role of Ca2+, ATP and compartmentation. Circ res 1981; 49: 1119-1128. W.Krause MS, Jacobus EW, Becker LC. Alterations in cardiac sarcoplasmic reticulum calcium trans