Dergiler / Medeniyet Medical Journal / 2016 / Cilt: 31 - Sayı: 4

Trachyspermum Ammi and Linum Usitatissimum are medicinal herbs used as hypolipidemic agents which protect against coronary artery disease

Trachyspermum Ammi ve Linum Usitatissimum hipolipidemik ajan olarak kullanılan bitkilerdir ve koroner arter hastalığından korur

Sayfa
282–286
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was concluded from this research work that Alsi and Ajwain given separately or in combination, have good enough potential to reduce LDL-cholesterol but are less potent effect on HDL-cholesterol in hyperlipidemic patients.

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Amaç & Hipotez:Abnormal deviations ratio between subgroups of low- density lipoprotein (LDL) cholesterol and high-density lipoprotein cholesterol (HDL) in human body predisposes to the formation of atherogenic plaques which are main etiological factors for the development of Coronary Artery Disease (CAD).
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Temel Bulgular & Veri:In this study we have used Trachyspermum Ammi (Ajwain; corn aniseed) and Linum Usitatissimum (Alsi, flaxseed) separately and in combination to investigate their anti-atherogenic and hypolipidemic features.
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Sonuç & Katkı:It was concluded from this research work that Alsi and Ajwain given separately or in combination, have good enough potential to reduce LDL-cholesterol but are less potent effect on HDL-cholesterol in hyperlipidemic patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:2016 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Abnormal deviations ratio between subgroups of low- density lipoprotein (LDL) cholesterol and high-density lipoprotein cholesterol (HDL) in human body predisposes to the formation of atherogenic plaques which are main etiological factors for the development of Coronary Artery Disease (CAD). Many hypolipidemic herbs have been tested in the literature to prevent the occurrence of CAD. In this study we have used Trachyspermum Ammi (Ajwain; corn aniseed) and Linum Usitatissimum (Alsi, flaxseed) separately and in combination to investigate their anti-atherogenic and hypolipidemic features. Research was conducted at a Lahore General Hospital of Pakistan from February to June 2016. One hundred patients suffering from hyperlipidemia who were followed up in lipid research clinic of Jinnah Hospital, Lahore-Pakistan were enrolled in and approved written consent was taken from all patients. All patients were assigned to four different groups each , comprising of 25 patients. For three months, Group-I was treated with Ajwain, Group-II with Alsi, and Group-III with Ajwain plus Alsi. After three months therapy it was observed that Ajwain reduced LDL-cholesterol 23.77 mg/dl and increased HDLcholesterol 3.3 mg/dl. Alsi reduced LDL-cholesterol 7.5 mg/dl and increased HDL-cholesterol 5.3 mg/dl. Whereas combination of both agents decreased LDL-cholesterol 16.1 mg/dl and increased HDL-cholesterol 6.6 mg/dl in three months therapy. It was concluded from this research work that Alsi and Ajwain given separately or in combination, have good enough potential to reduce LDL-cholesterol but are less potent effect on HDL-cholesterol in hyperlipidemic patients.

Abstract

Düşük dansiteli lipoprotein (LDL) ve yüksek dansiteli lipoprotein (HDL) kolesterol alt gruplarının oranlarındaki anormal sapmalar, insanlarda koroner arter hastalığı (KAH) gelişimi için temel bir etiyolojik faktör olan atreosklerotik plak oluşumuna zemin hazırlar. Literatürde KAH oluşumunun engellenmesine yönelik çeşitli hipolipidemik etkili bitkilerin test edildiği saptanmıştır. Biz de bu çalışmada, Trachyspermum Ammi (Ajvain, mısır anasonu) ve Linum Usitassimum (Alsi, keten tohumu) bitkilerinin ayrı ayrı ve beraber kullanımlarının anti-atherojenik ve hipolipidemik etkilerini araştırmayı planladık. Çalışma Pakistan Genel Hastanesi (General Hospital)’inde Şubat-Haziran 2016 tarihleri arasında yürütüldü. Çalışmaya, Pakistan Lahor Jinnah Hastanesi Lipid Araştırma Kliniğinde takip edilen yüz (100) hiperlipidemi hastası alındı. Olgular yazılı onamları alındıktan sonra her biri 25 hastadan oluşan dört farklı gruba atandı. Grup 1 için tek başına Ajvain, Grup 2 için tek başına Alsi, Grup 3 için ise Ajvain ve Alsi kombinasyon tedavisi 3 ay süre ile uygulandı. Üç aylık tedavi süresi sonrasında Ajvain grubunda LDL kolesterol seviyesinde 23.77 mg/dl düşüş ve HDL seviyesinde 3.3 mg/dl artış, Alsi grubunda LDL kolesterol seviyesinde 7,5 mg/dl düşüş ve HDL seviyesinde 5.3 mg/dl artış izlendi. İki ajanın kombine kullanıldığı grupta ise LDL kolesterol seviyesinde 16.1 mg/dl düşüş ile birlikte, HDL kolesterol seviyesinde 6.6 mg/dl artış gözlendi. Özetle bu çalışmada, hiperlipidemik hastalarda LDL kolesterolü düşürmede Ajvain ve Alsi’nin ayrı ayrı veya birlikte kullanılması durumunda güçlü bir etki gösterilmişken, HDL kolesterol seviyesini yükseltmede daha az etkili bulunmuştur.

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Bu Makaleye Atıf Yap

MEMON, M. A., HINGORA, M. A., NIAZ, K., MURAD, S., KHAN, M., QUDOOS, A., HAKRO, S. (2016). Trachyspermum Ammi and Linum Usitatissimum are medicinal herbs used as hypolipidemic agents which protect against coronary artery disease. Medeniyet Medical Journal, Cilt: 31 - Sayı: 4, 282–286. https://ajindex.com/articles/283372

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