Dergiler / Medeniyet Medical Journal / 2020 / Cilt: 35 - Sayı: 4

Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes

Multipl Skleroza Sekonder Optik Nöritli Hastalarda Optik Sinir Başı Değişiklikleri: Etkilenen ve Diğer Sağlıklı Gözlerin Karşılaştırılması

Sayfa
330–337
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Evaluation of the LC measurements can be important for early detection of optic nerve damage in patients with MS.

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Amaç & Hipotez:Objective: To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period.
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Temel Bulgular & Veri:Methods: The study included 20 cases diagnosed with relapsing-remitting MS with a history of ON attacks affecting one eye and in remission of MS and ON attacks for at least three months, and 28 randomly selected eyes of age- and sex-matched healthy controls.
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Sonuç & Katkı:Evaluation of the LC measurements can be important for early detection of optic nerve damage in patients with MS.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period. Methods: The study included 20 cases diagnosed with relapsing-remitting MS with a history of ON attacks affecting one eye and in remission of MS and ON attacks for at least three months, and 28 randomly selected eyes of age- and sex-matched healthy controls. In the MS group, the eyes affected by ON attack were assigned as Group 1 (MS+ON), their fellow unaffected eyes as Group 2 (MS-ON), and healthy control eyes as Group 3. The LC, peripapillary retinal nerve fiber layer (ppRNFL), and subfoveal choroidal thickness measurements were made by using OCT in all cases, and results were compared between the groups. Results: The mean LC thickness in MS+ON and MS-ON groups was significantly lower than the control group (p<0.001). There was no significant difference between MS+ON and MS-ON groups in terms of mean LC thickness (p=0.073). The mean ppRNFL in the MS+ON and MS-ON groups was statistically significantly lower than the control group (p=0.003, p=0.035, respectively). Conclusions: It is noteworthy that LC is significantly affected in eyes with MS who have not had a history of ON attack. Evaluation of the LC measurements can be important for early detection of optic nerve damage in patients with MS.

Abstract

Amaç: Multipl skleroz (MS) hastalarında optik koherens tomografi (OKT) ile yapılan lamina kribroza (LK) kalınlık ölçümlerinin ve optik nörit (ON) atağının bu ölçümlere olan etkisinin remisyon döneminde değerlendirilmesi. Yöntem: Relapsing-remitting MS tanısı alan ve tek gözden ON atağı geçirme hikayesi olan, en az üç aydır MS ve ON atağı remisyonda olan 20 olgu ile yaş, cinsiyet uyumlu 28 sağlıklı olgunun rasgele seçilen gözü dahil edildi. MS’li grupta; ON atağından etkilenen gözleri Grup 1 (MS+ON), ON atağından etkilenmeyen diğer sağlıklı gözleri Grup 2 (MS-ON), sağlıklı bireylerin gözleri ise Grup 3 olarak değerlendirildi. Olgulara çekilen OKT görüntülerinden ortalama LK, peripapiller retina sinir lifi tabakası (ppRSLT) ve subfoveal koroid (SFK) kalınlık ölçümleri gruplar arasında karşılaştırıldı. Bulgular: Ortalama LK kalınlığı MS+ON ve MS-ON gruplarında kontrol grubu ile karşılaştırıldığında anlamlı (p<0,001) olarak ince olduğu saptandı. MS+ON ve MS-ON grupları arasında ortalama LK kalınlık değeri karşılaştırıldığında ise anlamlı fark olmadığı görüldü (p=0,073). MS+ON ve MS-ON gruplarında ortalama ppRSLT kalınlığı kontrol grubu ile karşılaştırıldığında anlamlı düzeyde ince olduğu saptandı (sırasıyla, p=0,003, p=0,035). Sonuç: Çalışmamızda ON atağı geçirmemiş olan MS’li gözlerde LK’nin anlamlı düzeyde etkilenmiş olması dikkat çekicidir. MS’te bu ölçüml

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Bu Makaleye Atıf Yap

VURAL, E. T., YILDIZ, M. B., KÖSE, A. O., SUER, D., BALCI, S. Y., EMIR, C., YENEREL, N. M. (2020). Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes. Medeniyet Medical Journal, Cilt: 35 - Sayı: 4, 330–337. https://ajindex.com/articles/283201

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Kaynakça (13)

  1. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007
  2. [CrossRef] 2. The Optic Neuritis Study Group. Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol. 2008
  3. [CrossRef] 3. Fjeldstad C, Bemben M, Pardo G. Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography. J Clin Neurosci. 2011
  4. [CrossRef] 4. Saidha S, Al-Louzi O, Ratchford JN, et al. Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four-year study. Ann Neurol. 2015
  5. [CrossRef] 5. Wicki CA, Hanson JVM, Schippling S. Optical coherence tomography as a means to characterize visual pathway involvement in multiple sclerosis. Curr Opin Neurol. 2018
  6. [CrossRef] 6. Petzold A, Balcer LJ, Calabresi PA, et al. Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol. 2017
  7. [CrossRef] 7. Frohman EM, Dwyer MG, Frohman T, et al. Relationship of optic nevre and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study. J Neurol Sci. 2009
  8. [CrossRef] 8. Dorr J, Wernecke KD, Bock M, et al. Association of retinal and macular damage with brain atrophy in multiple sclerosis. PLoSOne. 2011
  9. e18132. [CrossRef] 9. Eslami F, Ghiasian M, Khanlarzade E, Moradi E. Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, A Cross-Sectional Study. Eye Brain. 2020
  10. [CrossRef] 10. Birkeldh U, Manouchehrinia A, Hietala A, et al. Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis. Mult Scler Relat Disord. 2019
  11. 101414. [CrossRef] 11. Albon J, Purslow PP, Karwatowski WS, Easty DL. Age related compliance of the lamina cribrosa in human eyes. Br J Ophthalmol. 2000
  12. [CrossRef] 12. Kagemann L, Ishikawa H, Wollstein G, et al. Ultrahighresolution spectral domain optical coherence tomography imaging of the lamina cribrosa. Ophthalmic Surg Lasers Imaging Retina. 2012
  13. [CrossRef] 13. Park YL, Park CK. Diagnostic Capability of Lamina Cribrosa Thickness by Enhanced Depth Imaging and Factors A