Granulomatous interstitial nephritis secondary to drug hypersensitivitiy: A case report

Abstract

Acute interstitial nephritis can result from a multitude of causes, including drug hypersensitivity, infections and as a component of certain diseases like sarcoidosis, Sjogren's syndrome and systemic lupus erythematosus. Therefore, renal biopsy findings have to be interpreted as part of the complete clinical picture. In this report, we present a case of granulomatous interstitial nephritis and renal insufficiency. The patient was a 46 year-old female presenting with fatigue, poor apetite, nausea and a history of recent multi-drug use including amoxycillin. The levels of blood urea nitrogen and creatinine were 29 mg/dL and 2.9 mg/dL, respectively. Urinalysis was significant for 15-20 white blood cells/high power field. Renal biopsy showed granulomatous interstitial nephritis. The patient was diagnosed as drug-induced interstitial nephritis and responded well to steroid therapy.