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Dergiler / Journal of Clinical Research in Pediatric Endocrinology / 2015 / Cilt: 7 - Sayı: 2

Nifedipine in Congenital Hyperinsulinism- A Case Report

Papiya KHAWASH
Khalid HUSSAIN
Sarah E FLANAGAN
Sudip CHATTERJEE
Dhananjoy BASAK
Sayfa
151–154
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Continuous glucose monitoring sensor was used as an aid to monitor glycaemic control and was found to be a safe and reliable option reducing the number of needle-pricks in small children.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates.
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Temel Bulgular & Veri:Recessive ABCC8 and KCNJ11 mutations are responsible for most (82%) of the severe diazoxideunresponsive CHI.
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Sonuç & Katkı:Continuous glucose monitoring sensor was used as an aid to monitor glycaemic control and was found to be a safe and reliable option reducing the number of needle-pricks in small children.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates. Diazoxide is the first-line drug in its treatment, but the more severe cases are usually diazoxide-resistant. Recessive ABCC8 and KCNJ11 mutations are responsible for most (82%) of the severe diazoxideunresponsive CHI. Oral nifedipine has been effective in isolated cases of CHI. Successful treatment of diazoxide-unresponsive CHI with a combination of octreotide and nifedipine has been reported in a single isolated case so far. We report here a case of diazoxide-resistant CHI due to homozygous ABCC8 nonsense mutation. In this case, hypoglycaemia uncontrolled by pancreatectomy and octreotide alone showed a good response to a combination of nifedipine and octreotide. Octreotide was tapered off by one year age and thereafter the child is euglycaemic on oral nifedipine alone. Continuous glucose monitoring sensor was used as an aid to monitor glycaemic control and was found to be a safe and reliable option reducing the number of needle-pricks in small children.

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Bu Makaleye Atıf Yap

KHAWASH, P., HUSSAIN, K., FLANAGAN, S. E., CHATTERJEE, S., BASAK, D. (2015). Nifedipine in Congenital Hyperinsulinism- A Case Report. Journal of Clinical Research in Pediatric Endocrinology, Cilt: 7 - Sayı: 2, 151–154. https://ajindex.com/articles/270528

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Kaynakça (5)

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