Dergiler / JAREM / 2018 / Cilt: 18 - Sayı: 3

A Rarely Seen Pathology "Intramedullary Spinal Metastasis"; Clinical Series of Five Patients in a Single Institution

Nadir Görülen Bir Patoloji "İntramedüller Spinal Metastaz"; Tek Bir Sağlık Merkezinde Beş Hastalık Klinik Bir Seri

Dergi
JAREM
Sayfa
138–146
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Planning the right treatment for the right patient is the most important step of ISCM management.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Our study is related to our experiences with intramedullary spinal cord metastasis (ISCM).
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Temel Bulgular & Veri:Methods: Five patients with ISCM who were admitted to the neurosurgery department between October 2011 and December 2016 and who underwent surgery were identified.
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Sonuç & Katkı:Planning the right treatment for the right patient is the most important step of ISCM management.
🔬Tür:Araştırma Makalesi
📍Kapsam:2011 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Our study is related to our experiences with intramedullary spinal cord metastasis (ISCM). The purpose of the present study was to evaluate the clinical features, treatment, and natural course of patients in the context of the literature. Methods: Five patients with ISCM who were admitted to the neurosurgery department between October 2011 and December 2016 and who underwent surgery were identified. Relevant clinical data were obtained. Results: Of the five patients, three had lung cancer, one had breast cancer, and one had renal cell carcinoma. The presenting symptoms were pain, urinary incontinence, and/or weakness. Tumors were at the thoracic level in three patients, cervical level in one patient, and thoracolumbar level in one patient. One patient with lung cancer had undergone metastasectomy for intracranial metastasis. The pathological examination of one patient had been reported as anaplastic ependymoma in a previous health facility, but breast cancer metastasis was found to be the primary diagnosis following the examination of the material obtained from the excision of the relapsed tumor. Conclusion: The diagnosis of ISCM is difficult, and treatment is usually ineffective. Although there is no exact treatment modality in ISCM, appropriate surgery positively affects morbidity and mortality. Planning the right treatment for the right patient is the most important step of ISCM management.

Abstract

Amaç: Bu çalışma intramedüller spinal kord metastazı olan (ISCM) hastalardan edindiğimiz tecrübe ile ilgilidir ve bizim amacımız bu hastaları klinik özelliği, tedavisi ve doğal seyirinin literatürdeki hastalarla birlikte değerlendirmektir. Yöntemler: Beyin ve sinir cerrahisi kliniğine Ekim 2011-Aralık 2016 tarihleri arasında başvuran ve ameliyat edilen beş ISCM hastası seçildi. Bu hastalarla ilişkili bilgiler elde edildi. Bulgular: Üç hastanın akciğer kanseri, bir hastanın meme kanseri ve bir hastanın renal cell kanseri olduğu saptandı. Başvuru bulguları ağrı, idrar inkontinansı ve/veya güçsüzlüktü. Üç hastada tümör torasik seviyede, bir hastada servikal seviyede ve bir hastada torakolomber bileşke düzeyindeydi. Akciğer kanseri olan hastalardan birinde öncesinde intrakranyal metastazektomi operasyonu mevcuttu. Daha önce başka bir sağlık merkezinde opere edilen hastada patoloji sonucu anaplastic ependimoma olarak raporlanmıştı. Fakat nüks tümör eksizyonu operasyonu sonrası primer tanının meme kanseri metastazı olduğu saptandı. Sonuç: ISCM tanısı zordur ve tedavisi genellikle yetersizdir. ISCM için net bir tedavi modeli bulunmamakla beraber, uygun cerrahi morbidite ve mortaliteyi olumlu etkiler. ISCM yönetiminde doğru hastaya doğru tedaviyi planlamak en önemli adımdır.

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Bu Makaleye Atıf Yap

AKYUVA, Y., KARADAĞ, N., ÖNAL, S. Ç. (2018). A Rarely Seen Pathology "Intramedullary Spinal Metastasis"; Clinical Series of Five Patients in a Single Institution. JAREM, Cilt: 18 - Sayı: 3, 138–146. https://ajindex.com/articles/270421

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Kaynakça (14)

  1. Grasso G, Meli F, Patti R, Giambartino F, Florena AM, Iacopino DG. Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature. Spinal Cord 2007
  2. [CrossRef] 2. Mut M, Schiff D, Shaffrey ME. Metastasis to nervous system: spinal epidural and intramedullary metastases. J Neurooncol 2005
  3. [CrossRef] 3. Jacobs WB, Perrin RG. Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 2001
  4. e10. [CrossRef] 4. Diehn FE, Rykken JB, Wald JT, Wood CP, Eckel LJ, Hunt CH, et al. Intramedullary spinal cord metastases: prognostic value of MRI and clinical features from a 13-year institutional case series. AJNR Am J Neuroradiol 2015
  5. [CrossRef] 5. Lee EQ. Nervous system metastases from systemic cancer. Continuum 2015
  6. [CrossRef] 6. Schiff D, O’Neill BP. Intramedullary spinal cord metastases: clinical features and treatment outcome. J Neurooncol 1996
  7. [CrossRef] 7. Dunne JW, Harper CG, Pamphlett R. Intramedullary spinal cord metastases: a clinical and pathological study of nine cases. Q J Med 1986
  8. Fakih M, Schiff D, Erlich R, Logan TF. Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases. Ann Oncol 2001
  9. [CrossRef] 9. Asad S, Sher I, Peters-Willke J, Jessup P. Neurotropic cutaneous malignant melanoma with contiguous spread to spinal cord, an extremely rare presentation. J Spine Surg 2016
  10. [CrossRef] 10. Minomo S, Tokoro A, Utsumi T, Ishihara M, Akira M, Atagi S. A case of long-term survival after multimodal local treatments of intramedullary spinal cord metastasis of squamous cell lung cancer. J Thorac Dis 2016
  11. E681-3. [CrossRef] 11. Hashii H, Mizumoto M, Kanemoto A, Harada H, Asakura H, Hashimoto T, et al. Radiotherapy for patients with symptomatic intramedullary spinal cord metastasis. J Radiat Res 2011
  12. [CrossRef] 12. Ding D, Fullard M, Jarrell HS, Jones DE. Intramedullary spinal cord metastasis from salivary ductal carcinoma of the parotid gland mimicking transverse myelitis in a patient with radiologically isolated syndrome. J Neurol Sci 2014
  13. [CrossRef] 13. Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH, et al. Empirical evidence of design-related bias in studies of diagnostic tests. Jama 1999
  14. [CrossRef] 14. Nishio S, Fukui M, Sato Y, Araki K. Intramedullary spin