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AI InsightIt is thought that the difference may be statistically significant when the study is performed with kidney volume analysis and larger patient population
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Özet
Aim: There is no enough data on pulmonary involvement in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study is to examine pulmonary function test in patients with ADPKD with varying stages of renal function and to compare them with those in healthy controls. Methods: Forty-six patients with ADPKD and 43 healthy control subjects were included in the study. Pulmonary function test was performed for each patient after routine physical examination and biochemical analysis. Results: Age, gender, weight, height and smoking rate were similar in both groups. Seven patients (15.2%) had restrictive pattern and one (2.1%) had obstructive pattern in ADPKD group while one patient (2.3%) had obstructive pattern and two (4.6%) had restrictive pattern in the control group. The frequency of restrictive pattern was not significantly higher (p=0.15), but forced vital capacity volume was significantly lower in the patient group (p=0.04). Conclusion: Restrictive spirometric pattern was more prevalent in the patient group, but there was no statistically significant difference. It is thought that the difference may be statistically significant when the study is performed with kidney volume analysis and larger patient population
Abstract
Amaç: Otozomal dominant polikistik böbrek hastalığında (ODPBH) akciğer tutulumu için literatürde yeterli veri yoktur. Bu çalışmanın amacı, ODPBH’nin ve farklı evrelerinini, solunum fonksiyon testleri üzerine etkisini incelemektir. Yöntemler: Kırk altı ODPBH hastası ve 43 sağlıklı kontrol olgusu çalışmaya dahil edildi. Her olgu için rutin fizik muayene ve biyokimyasal analizden sonra solunum fonksiyon testleri yapıldı. Bulgular: Yaş, cinsiyet, kilo, boy ve sigara içme oranı her iki grupta benzerdi. Otozomal dominant polikistik böbrek hastalığı grubunda yedi hastada (%15,2) restriktif patern, bir hastada (%2,1) obstrüktif patern, kontrol grubunda bir hastada (%2,3) obstrüktif patern, iki hastada (%4,6) restriktif patern tespit edildi. Restriktif patern, iki grupta benzer olmakla birlikte (p=0,15), zorlu vital kapasite hacmi hasta grubunda anlamlı olarak düşüktü (p=0,04). Sonuç: Hasta grubunda restriktif spirometrik patern daha sık görüldü, ancak istatistiksel olarak anlamlı bir fark yoktu. Çalışma böbrek hacim analizi ve daha büyük hasta popülasyonu ile yapıldığında, farkın istatistiksel olarak anlamlı olabileceği düşünülmektedir.