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Dergiler / Hacettepe Journal of Biology and Chemistry / 2007 / Cilt: 35 - Sayı: 1

Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats

Ayşegül AKBAY YARPUZLU
Yeşim UĞUR
Ayşegül NAZİKOĞLU
Esin ASAN
İlkay YİLDİZ
Sayfa
25–30
Yayın Tarihi
2007-01-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team.
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Temel Bulgular & Veri:Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 .
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Sonuç & Katkı:Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:AIDS · HIV-RT inhibitor · 2-phenoxymethyl-5-chlorobenzimidazole

Abstract

Introduction2-Phenoxymethyl-5-chlorobenzimidazole is a substituted benzimidazole that has been synthesized by our team. Benzimidazoles and their substituted derivatives have been used as antimicrobials in the treatment of Pneumocystis pneumonia 1 , Helicobacter pylori 2 , in plant protection 3 , as antivirals against cytomegalovirus 4 , as well as antiparasitics against Giardia lamblia 5 and some Microsporidia species such as Encephalitozoon hellem and Encephalitozoon intestinalis 6 by binding to the cytoskeleton 7 . Some have also been shown to be inhibitors of HIV-RT 8 , and Adenosine Deaminase ADA 9

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Bu Makaleye Atıf Yap

YARPUZLU, A. A., UĞUR, Y., NAZİKOĞLU, A., ASAN, E., YİLDİZ, İ. (2007). Investigation of Renal Histopathological Changes Due to HIV-RT Inhibitor 2-phenoxymethyl-5-chlorobenzimidazole Administration in Rats. Hacettepe Journal of Biology and Chemistry, Cilt: 35 - Sayı: 1, 25–30. https://ajindex.com/articles/256165

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Kaynakça (11)

  1. Fishman JA. Treatment of Infection Due to Pneumocystis carini. Antimicrobial Agents and Chemotherapy. 1998; 42;6:1309-1314
  2. Hof H. Critical Annotations to the Use of Azole Antifungals for Plant Protection. Antimicrobial Agents Chemother. 2001; 45;11:2987-2990
  3. Chiba N, von Zanten SJ, Sinclair P, Ferguson RA, Escobedo S, Grace E. Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive ( CADET-Hp) randomised controlled trial. BMJ 2002,324;7344:1012
  4. Buerger I, Reefschlaeger J, Bender W, Eckenberg P, Popp A, Weber O, Graeger S, Klenk HD, Ruebsamen,Waigmann H, Hallenberger S. A Novel Nonnucleoside Inhibitor Specifically Targets Cytomegalovirus DNA Maturation via the UL89 and UL56 Gene Products. J. Virol.2001,75;19:9077-9086
  5. Adam RD. Biology of Giardia lamblia. Clin Microbiol Rev. 2001,14;3:447-475
  6. Ridoux O, Drancourt M. In vitro Susceptibilies of the Microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem and Encephalitozoon intestinalis to Albendozole and its sulfoxide and sulfone Metabolites. Antimicrob Agents Chemother. 1998,42;12: 3301-3303
  7. Morrissette NS. Sibley LD. Cytoskeleton to Amplicomplexon Parasites. Microbiol Mol Biol Rev. 2002,66;1:21-38
  8. Akbay A, Ören Ý, Temiz-Arpacý Ö, Aký-Þener E, Yalçýn Ý. Synthesis and HIV-1 Reverse transcriptase Inhibitor Activity of Some 2,5,6-Substituted Benzoxazole, Benzimidazole, Benzthiazole and Oxazolo (4,5-b) pyridine Derivatives. ArzneimForschDrugRes. 2003,53;4:266-71
  9. Yarpuzlu Akbay A, Yýldýz Ý, Temiz-Arpacý Ö, Karagenç N, Aki-Þener E, Yalçýn Ý. Adenosine Deaminase Inhibitor Activity of Some Benzoxazole, Benzimidazole and Oxazolo (4,5-b) pyridine Derivatives. XIII. Biyoteknoloji Kongresi Bildiriler Kitabý, 25-29 Aðustos 2003 Çanakkale sf.21-26
  10. Arterburn LM, Zurlo J, Yager JD, Overton RM, Heifetz AH. A morphological study of differentiated hepatocytes in vitro. Hepatology. 1995, 22;1:175-187,1995
  11. Associated Intestinal Tract Organs, Part 25 Liver, pages:575-591 in Histology for Pathologists, edited by Sternberg SS. Second edition, Lippincott-Raven Publishers 1997, Philadelphia.