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Dergiler / Hacettepe Journal of Biology and Chemistry / 2010 / Cilt: 38 - Sayı: 4

The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan

Abdullah OLGUN
Zeynep KÖKSAL
Abdulkadir ÇOBAN
Sayfa
287–290
Yayın Tarihi
2010-12-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Our results can be helpful in future studies on TUDCA which is a very important and promising therapeutical agent.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Endoplasmic reticulum ER stress is involved in many diseases including diabetes, cancer and aging.
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Temel Bulgular & Veri:We tested TUDCA at the concentrations of 0.625, 1.25, 2.5, 3.75, 5, 7.5, 10, 15 and 20 mM.
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Sonuç & Katkı:Our results can be helpful in future studies on TUDCA which is a very important and promising therapeutical agent.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Endoplasmic reticulum stress · Tauroursodeoxycholic acid · Caenorhabditis elegans

Abstract

Endoplasmic reticulum ER stress is involved in many diseases including diabetes, cancer and aging. Tauroursodeoxycholic acid TUDCA is a chemical chaperone that reduces ER stress. Caenorhabditis elegans C. elegans , a widely used model organism in aging studies, also suffers from ER stress. In this study, we tested the effect of TUDCA on C. elegans life span with the aim to decipher the contribution of ER stress on C. elegans aging. We tested TUDCA at the concentrations of 0.625, 1.25, 2.5, 3.75, 5, 7.5, 10, 15 and 20 mM. It showed a negative effect on the life span at all of the tested concentrations except 3.75 mM. At this concentration it had no toxicity nor an effect on longevity. One of the previously reported critical micellar concentrations CMC of TUDCA is closer to this concentration. Therefore TUDCA’s mechanism of action could be explained, at least in part, by its micelle formation. It could have exerted negative effects at both lower and higher concentrations than CMC. If it had a positive effect on life span through ameliorating ER stress at the CMC, this could have been neutralized by its partial toxicity. Our results can be helpful in future studies on TUDCA which is a very important and promising therapeutical agent.

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Bu Makaleye Atıf Yap

OLGUN, A., KÖKSAL, Z., ÇOBAN, A. (2010). The Effect of Reducing Endoplasmic Reticulum Stress by Tauroursodeoxycholic Acid on Caenorhabditis elegans Lifespan. Hacettepe Journal of Biology and Chemistry, Cilt: 38 - Sayı: 4, 287–290. https://ajindex.com/articles/256120

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