The activity of the enzyme were significantly higher in AA groups (p
📌 3 Maddede Bu Makale
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Amaç & Hipotez:It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases.
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Temel Bulgular & Veri:The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism.
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Sonuç & Katkı:The activity of the enzyme were significantly higher in AA groups (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Oxidative stress · acute appendicitis · cellular defense system
Abstract
It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p
TEMİZ, A., IŞIK, M., ALBAYRAK, Y., DURAN, H. E., ASLAN, A., DEMİR, Y., ALBAYRAK, A., IŞIK, M., BEYDEMİR, Ş. (2021). The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis. Hacettepe Journal of Biology and Chemistry, Cilt: 49 - Sayı: 1, 69–78. https://ajindex.com/articles/255856
D.J. Shogilev, N. Duus, S.R. Odom, N.I. Shapiro, Diagnosing appendicitis: Evidence-based review of the diagnostic approach in 2014, West. J. Emerg. Med., 15 (2014) 859-871
Y. Albayrak, A. Albayrak, M. Celik, I. Gelincik, I. Demiryilmaz, R. Yildirim, B. Ozogul, High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis, Scand. J. Trauma. Resusc. Emerg. Med., 20 (2011) 19-27
Y. Albayrak, A. Albayrak, F. Albayrak, R. Yildirim, B. Aylu, A. Uyanik, E. Kabalar, I.C. Güzel, Mean platelet volume: A new predictor in confirming acute appendicitis diagnosis, Clin. Appl. Thromb., 17 (2011) 362-366
M.L. Nance, W.T. Adamson, H.L. Hedrick, Appendicitis in the young child: A continuing diagnostic challenge, Pediatr. Emerg. Care., 16 (2000) 160–162
D.R. Flum, T. Koepsell, The clinical and economic correlates of misdiagnosed appendicitis: Nationwide analysis, Arch. Surg., 137 (2002) 799–804
F.M. Yilmaz, G. Yilmaz, M.F. Erol, S. Köklü, D. Yücel, Nitric oxide, lipid peroxidation and total thiol levels in acute appendicitis, J. Clin. Lab. Anal., 24 (2010) 63–66
H. SIES, Strategies of antioxidant defense, Eur. J. Biochem., 215 (1993) 213–219
V. Stojiljković, A. Todorović, N. Radlović, S. Pejić, M. Mladenović, J. Kasapović, S.B. Pajović, Antioxidant enzymes, glutathione and lipid peroxidation in peripheral blood of children affected by coeliac disease, Ann. Clin. Biochem., 44 (2007) 537-543
J.E. Klaunig, Y. Xu, J.S. Isenberg, S. Bachowski, K.L. Kolaja, J. Jiang, D.E. Stevenson, E.F. Walborg, The role of oxidative stress in chemical carcinogenesis, in: Environ. Health Perspect., 44 (1998) 239–267
S.L. de Oliveira Machado, M.D. Bagatini, P. da Costa, J. Baldissarelli, K.P. Reichert, L.S. de Oliveira, J.G. Lemos, T. Duarte, M.R. Chitolina Schetinger,. V.M. Morsch, Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis, Biomarkers., 21 (2016) 530-537
C. Espinosa-Diez, V. Miguel, D. Mennerich, T. Kietzmann, P. Sánchez-Pérez, S. Cadenas, S. Lamas, Antioxidant responses and cellular adjustments to oxidative stress, Redox Biol., 6 (2015) 183-197
M.M. Işgör, Ş. Beydemir, Some cardiovascular therapeutics inhibit paraoxonase 1 (PON1) from human serum, Eur. J. Pharmacol., 645 (2010) 135-142
H. Paşaoǧlu, B. Sancak, N. Bukan, Lipid peroxidation and resistance to oxidation in patients with type 2 diabetes mellitus, Tohoku J. Exp. Med., 203 (2004) 211–2