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Dergiler / Hacettepe Journal of Biology and Chemistry / 2018 / Cilt: 46 - Sayı: 3

Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule

Gamze KOZ
Sayfa
373–380
Yayın Tarihi
2018-09-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The physicochemical properties of the molecule such as frontier molecule orbitals and chemical reactivity parameters were also investigated.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A novel uracil derived compound, (E)-5-((3-chloro-2-hydroxybenzylidene)amino) pyrimidine-2,4(1H,3H)- dione, was synthesized and characterized using spectroscopic techniques.
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Temel Bulgular & Veri:The interaction of the molecule with DNA was explored using computational methods which revealed that the molecule could act as a groove binder.
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Sonuç & Katkı:The physicochemical properties of the molecule such as frontier molecule orbitals and chemical reactivity parameters were also investigated.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Uracil · Schiff base · DNA binding

Abstract

A novel uracil derived compound, (E)-5-((3-chloro-2-hydroxybenzylidene)amino) pyrimidine-2,4(1H,3H)- dione, was synthesized and characterized using spectroscopic techniques. The interaction of the molecule with DNA was explored using computational methods which revealed that the molecule could act as a groove binder. The physicochemical properties of the molecule such as frontier molecule orbitals and chemical reactivity parameters were also investigated.

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Bu Makaleye Atıf Yap

KOZ, G. (2018). Synthesis, Structural Calculations and Molecular Docking Studies of a Novel Uracil Derived Organic Molecule. Hacettepe Journal of Biology and Chemistry, Cilt: 46 - Sayı: 3, 373–380. https://ajindex.com/articles/255831

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Kaynakça (9)

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