KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 3

Effects of the medial or basolateral amygdala upon social anxiety and social recognition in mice

Yu WANG
Shanshan ZHAO
Xu LIU
Qunying FU
Sayfa
353–359
Yayın Tarihi
2014-05-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Moreover, both the medial and the basolateral amygdala are essential for social recognition but not flavor recognition in mice.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined.
📊
Temel Bulgular & Veri:Materials and methods: Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl-D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition test, and flavor recognition test.
💡
Sonuç & Katkı:Moreover, both the medial and the basolateral amygdala are essential for social recognition but not flavor recognition in mice.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Medial amygdala · basolateral amygdala · social anxiety

Özet

Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined. This study investigated the effects of excitotoxic bilateral medial or basolateral amygdala lesions upon social anxiety and social recognition in mice. Materials and methods: Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl-D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition test, and flavor recognition test. Results: Medial or basolateral amygdala-lesioned mice showed lower levels of anxiety and increased social behaviors in a novel environment. Destruction of the medial or basolateral amygdala neurons impaired social recognition but not flavor recognition. Conclusion: The medial or basolateral amygdala is involved in the control of anxiety-related behavior (social anxiety and social behaviors) in mice. Moreover, both the medial and the basolateral amygdala are essential for social recognition but not flavor recognition in mice.

Abstract

Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined. This study investigated the effects of excitotoxic bilateral medial or basolateral amygdala lesions upon social anxiety and social recognition in mice. Materials and methods: Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl-D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition test, and flavor recognition test. Results: Medial or basolateral amygdala-lesioned mice showed lower levels of anxiety and increased social behaviors in a novel environment. Destruction of the medial or basolateral amygdala neurons impaired social recognition but not flavor recognition. Conclusion: The medial or basolateral amygdala is involved in the control of anxiety-related behavior (social anxiety and social behaviors) in mice. Moreover, both the medial and the basolateral amygdala are essential for social recognition but not flavor recognition in mice.

🔖

Bu Makaleye Atıf Yap

WANG, Y., ZHAO, S., LIU, X., FU, Q. (2014). Effects of the medial or basolateral amygdala upon social anxiety and social recognition in mice. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 3, 353–359. https://ajindex.com/articles/228082

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (9)

  1. Arslan Z, Özmen S, Sürmeli S, Arda N. Atypical acute urticaria in children and its relationship with urticarial vasculitis. Turk J Med Sci 2011; 41: 87–92.
  2. Shinoura N, Yamada R, Tabei Y, Otani R, Itoi C, Saito S, Midorikawa A. Left or right temporal lesion might induce aggression or escape during awake surgery, respectively: role of the amygdala. Acta Neuropsychiatrica 2011; 23: 119–124.
  3. Omar-Abdel O, Nada S. Piracetam reverses haloperidol-induced catalepsy in mice. Turk J Med Sci 2011; 41: 693–699. Aggleton JP. The contribution of the amygdala to normal and abnormal emotional states. Trends Neurosci 1993; 16: 328–333. LeDoux JE. The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York: Touchstone Press; 1996.
  4. Adamec R, Shallow T. Effects of baseline anxiety on response to kindling of the right medial amygdala. Physiol Behav 2000; 70: 67– Ertekin V, Sümbüllu MA, Tosun MS, Selimoğlu MA, Kara M, Kılıç N. Oral findings in children with celiac disease. Turk J Med Sci 2012; 42: 613–617. ohn CS, Currie PJ. N-Arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze. Behav Brain Res 2012; 233: 382–388.
  5. Xu C, Yi CJ, Guo HD, Liu QQ, Wang L, Li HX. Limb remote ischemic postconditioning is effective but also time-courselimited in protecting the brain from I/R injury. Turk J Med Sci 2012; 42: 918–929. Neumann ID. The miracle of brain neuropeptides: targeting the brain oxytocin is a true treatment option in numerous psychiatric disorders including schizophrenia. Acta Neuropsychiatrica 2012; 24: 127–129.
  6. Takayanagi Y, Takashima A, Onaka T. Secretin facilitates social behaviors via activation of oxytocin receptors. Neurosci Res 2010; 685: e412. Ahmed HH, Shousha WG, Hussien RM, Farrag ARH. Potential role of some nutraceuticals in the regression of Alzheimer’s disease in an experimental animal model. Turk J Med Sci 2011; 41: 455–466.
  7. Aygün D, Türkel Y, Akkurt A, Onar MK. The effects of REM sleep behaviour disorder on clinical severity in Parkinson’s disease. Turk J Med Sci 2012; 42: 1033–1038.
  8. Ünlü ŞM, Çelik A, Sağlam Eyiler F, Ersan S, Sarıoğlu S. Cortical and medullary vascularity in renal allograft biopsies. Turk J Med Sci 2012; 42: 713–717.
  9. Liu ML, Li ZK. Effects of androgen on expression of OMgp of the HIBD neonatal rat brain. Turk J Med Sci 2012; 42: 1319– 13 Söğüt Ö, Kaya H, Gökdemir MT, Solduk L, Dokuzoğlu MA, Sayhan MB, Kaya A, Koçyiğit A. Early oxidative status in adult patients with isolated