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Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2005 / Cilt: 11 - Sayı: 1

Can methotrexate induce tubal abortion?: A report of three cases

Murat DEDE
ÜMİT GÖKTOLGA
Müfit Cemal YENEN
Namık Kemal DURU
Tansu KÜÇÜK
İskender BAŞER
Sayfa
64–65
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Tubal abortion was observed in all three cases with no tubal rupture at laparoscopy (1) Tubal abortion may be a result of extraction of ectopic pregnancy material by tubal peristaltism from the fimbrial end, which was lysed and gotten smaller by the antimetabolic affect of methotrexate. (2) Surgical intervention may be delayed even if the clinical symptoms of tubal rupture had occurred and expectant management with close observation should be a suitable way of follow up for these patients because of tubal abortion probability.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:To report tubal abortion observed in laparoscopy in three tubal ectopic pregnancy cases.
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Temel Bulgular & Veri:Laparoscopic evaluation has been made for sudden pelvic pain suggesting of clinical tubal rupture symptoms on third day following single dose of IM Methotrexate (50 mg/m2) injection.
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Sonuç & Katkı:Tubal abortion was observed in all three cases with no tubal rupture at laparoscopy (1) Tubal abortion may be a result of extraction of ectopic pregnancy material by tubal peristaltism from the fimbrial end, which was lysed and gotten smaller by the antimetabolic affect of methotrexate. (2) Surgical intervention may be delayed even if the clinical symptoms of tubal rupture had occurred and expectant management with close observation should be a suitable way of follow up for these patients because of tubal abortion probability.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Gebelik · ektopik · Methotreksat

Abstract

To report tubal abortion observed in laparoscopy in three tubal ectopic pregnancy cases. Laparoscopic evaluation has been made for sudden pelvic pain suggesting of clinical tubal rupture symptoms on third day following single dose of IM Methotrexate (50 mg/m2) injection. Tubal abortion was observed in all three cases with no tubal rupture at laparoscopy (1) Tubal abortion may be a result of extraction of ectopic pregnancy material by tubal peristaltism from the fimbrial end, which was lysed and gotten smaller by the antimetabolic affect of methotrexate. (2) Surgical intervention may be delayed even if the clinical symptoms of tubal rupture had occurred and expectant management with close observation should be a suitable way of follow up for these patients because of tubal abortion probability.

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Bu Makaleye Atıf Yap

DEDE, M., GÖKTOLGA, Ü., YENEN, M. C., DURU, N. K., KÜÇÜK, T., BAŞER, İ. (2005). Can methotrexate induce tubal abortion?: A report of three cases. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 11 - Sayı: 1, 64–65. https://ajindex.com/articles/227564

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Kaynakça (7)

  1. Centers for Disease Control, Abortion surveillance: preliminary analysis-United States, 1995; MMWR 46:1133-998
  2. Centers for Disease Control, http: //www.cdc.gov
  3. Stovall TG, Ling FW, Gray LA, Carson SA, Buster JE. Methotrexate treatment of unruptured ectopic pregnancy; a report of 100 cases. Obstet Gynecol 1991; 77:749-53
  4. Limpcomb G, Bran D, Me Cord M, Portera J, Ling F.Analysis of three hundred fifteen ectopic pregnancies treated with single dose methotrexate. Am J Obstet Gynecol 1998; 178:1354-8
  5. Speroff L, Glass R.H, Kase N.G. Clinical gynecologic endocrinology and infertility. Sixth edition. Lippincott Williams&Wilkins 1999 6. Sowter M.C, Farquhar CM, Petrie KJ, Gudex G.A randomized trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. Br J Obstet Gynecol 2001; 108:192-203
  6. Anandakumar C, Choolani MA, Adaikan PG, Wong YC, Gopal M, Marshall B, Ratnam SS. Combined chemotherapy in the medical management of tubal pregnancy. Aus N Z J Obstet Gynecol 1995; 35:437-40
  7. Limpcomb GH, Puckett KJ, Bran D, Ling FW. Management of separation pain after single-dose methotrexate therapy for ectopic pregnancy. Prim Care Update Ob Gyns 1998; 5:175.