The levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with polycystic ovary syndrome

Amaç & Hipotez:Objective: Recent evidence suggests that insulin-like growth factor system may have pathophysiological implication on polycystic ovary syndrome.

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Temel Bulgular & Veri:To address this issue, we attempted to evaluate the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with polycystic ovary syndrome.

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Sonuç & Katkı:Large population-based studies are needed to clarify this confusion.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:İnsülin-benzeri büyüme faktörü I · Polikistik yumurtalık sendromu · Vücut kitle indeksi

Abstract

Objective: Recent evidence suggests that insulin-like growth factor system may have pathophysiological implication on polycystic ovary syndrome. To address this issue, we attempted to evaluate the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with polycystic ovary syndrome. Study Design: We evaluated the levels of sex steroids in women with polycystic ovary syndrome, and compared with age-matched controls. Furthermore, any relationship between insulin-like growth factor and sex steroids was investigated. Results: The women with polycystic ovary syndrome had both hyperandrogenism and hyperinsulinemia. The level of insulin-like growth factor-1 was significantly higher in women with polycystic ovary syndrome regardless their body mass index. Furthermore, insulin-like growth factor-1 showed significant correlation with the levels of androstenedione, testosterone and dehydroepiandrosterone sulphate. Conclusion: This study had contradictory results with recent published literature. This may reflect the differences about patient selection, definition of polycystic ovary syndrome, and genetic and regional differences. Large population-based studies are needed to clarify this confusion.

Anahtar kelimeler

İnsülin-benzeri büyüme faktörü I Polikistik yumurtalık sendromu Vücut kitle indeksi Hiperandrojenizm İnsülin-benzeri büyüme faktörü bağlayıcı proteinler Hiperinsülinizm Yaş faktörü Insulin-Like Growth Factor I Polycystic Ovary Syndrome Body Mass Index Hyperandrogenism Insulin-Like Growth Factor Binding Proteins Hyperinsulinism Age Factors

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Bu Makaleye Atıf Yap

TOK, E. C., ERTUNÇ, D., AKTAŞ, A., DİLEK, S. (2005). The levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with polycystic ovary syndrome. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 11 - Sayı: 2, 103–106. https://ajindex.com/articles/227117

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Kaynakça (14)

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