Dergiler / Ege Tıp Dergisi / 2019 / Cilt: 58 - Sayı: 1

Changes in ghrelin, leptin and insulin levels after laparoscopic sleeve gastrectomy

Laparoskopik sleeve gastrektomi sonrası grelin, leptin ve insülin düzeylerindeki değişiklikler

Sayfa
21–26
DOI
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After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.

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Amaç & Hipotez:Aim: The objective of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG), performed upon patients with morbid obesity, on weight loss and recovery of comorbid diseases as well as on metabolic and hormonal mechanisms by comparing pre and postoperative hormone levels.
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Temel Bulgular & Veri:Materials and Methods: 38 patients having undergone LSG between May 2013 and May 2014 were included in the study.
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Sonuç & Katkı:After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2013 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: The objective of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG), performed upon patients with morbid obesity, on weight loss and recovery of comorbid diseases as well as on metabolic and hormonal mechanisms by comparing pre and postoperative hormone levels. Materials and Methods: 38 patients having undergone LSG between May 2013 and May 2014 were included in the study. In this prospective study, patients’ demographic data and associated diseases; weight loss; pre and postoperative insulin levels in addition to pre and post-operative leptin and ghrelin levels in the eighth weeks were compared. Results: Of 38 patients included in the study there were 32 (84.2%) females and 6 (15.8%) males. Median leptin level was 11.16 ng/mL in the preoperative blood sample, whereas postoperative hormone level in the eighth week was 4.39 ng/mL. When ghrelin levels were examined; preoperative median was 25.72 pg/mL, whereas postoperative hormone level was 14.16 pg/mL in the eighth week. Preoperative median body mass index was determined to be 44.27 and post-operative median was observed to be 36.6 in the eighth week. No mortality was observed. Conclusion: Today LSG has become a unique surgical technique in the treatment of morbid obesity due to its efficiency in obtaining weight loss and its feasible complication rates. After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.

Abstract

Amaç: Bu çalışmada, morbid obezite tanılı hastalarda tedavi amacıyla uygulanan LSG’nin kilo kaybı ve yandaş hastalıkların tedavisinin yanı sıra metabolik ve hormonal mekanizmalar üzerindeki etkinliğinin, operasyon öncesi ve operasyon sonrası dönemdeki hormon düzeyleri karşılaştırılarak irdelenmesi amaçlandı. Gereç ve Yöntemler: Mayıs 2013-Mayıs 2014 tarihleri arasında, LSG uygulanan 38 hasta çalışmaya dahil edildi. Prospektif olan bu çalışmada hastaların demografik verileri, yandaş hastalıkları, takipte kilo kaybı, morbidite ve mortalite oranları, operasyon öncesi ve sonrası insülin düzeyleri ile operasyon öncesi ve operasyon sonrası sekizinci haftadaki leptin ve grelin hormonlarının düzeyleri irdelenerek karşılaştırıldı. Bulgular: Çalışmaya dahil edilen 38 hastadan 32’si (%84,2) kadın, altısı (%15,8) ise erkekti. Operasyon öncesi alınan kandaki leptin düzeylerinin ortalaması 11,16 ng/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 4,39 ng/mL olarak belirlendi. Grelin düzeylerine bakıldığında ise; operasyon öncesi ortalama 25,72 pg/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 14,16 pg/mL olarak belirlendi. Operasyon öncesi ortalama vücut kitle indeksi (VKİ) 44,3, operasyon sonrası sekizinci haftada ise 36,6 olarak belirlendi. Hiçbir hastada mortalite gözlenmedi. Sonuç: LSG, günümüzde mükemmel kilo kaybı sağlaması ve kabul edilebilir oranlarda düşük komplikasyon riskleri nedeniyle morbid obezite tedavisinde tek başına uygulanan bir cerrahi teknik haline gelmiştir. Çalışmamızın sonuçlarına baktığımız zaman; bu ameliyat tekniğinin sadece restriktif değil, aynı zamanda metabolik değişikliklere neden olarak da kilo kaybındaki devamlılığı sağladığı kanaatindeyiz.

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Bu Makaleye Atıf Yap

EROL, V., AYDİN, C., UĞURLU, L., TURGUT, E., YALÇIN, H., ARSLAN, F. D. (2019). Changes in ghrelin, leptin and insulin levels after laparoscopic sleeve gastrectomy. Ege Tıp Dergisi, Cilt: 58 - Sayı: 1, 21–26. https://ajindex.com/articles/222680

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