Dergiler / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 3

Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy

Laparoskopik ve Abdominal Histerektomide Doku Travma Belirteçlerinin Karşılaştırılması

Sayfa
356–363
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies conducted with inflammatory markers other than PTX-3 and NLR are required to elucidate the choice of surgery technique in similar patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: To compare abdominal and laparoscopic techniques of hysterectomy in terms of the surgery-induced trauma with measuring serum Pentraxin-3 (PTX3) level and neutrophil to lymphocyte ratio (NLR).
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Temel Bulgular & Veri:Materials and Methods: In this study, preoperative and postoperative blood samples were used to compare the change at the level of PTX-3 and NLR in order to evaluate the inflammatory response in 40 patients, of whom, 20 had experienced Total Laparoscopic Hysterectomy (TLH) + Bilateral SalpingoOophorectomy (BSO) and 20 had experienced Total Abdominal Hysterectomy (TAH + BSO).
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Sonuç & Katkı:Further studies conducted with inflammatory markers other than PTX-3 and NLR are required to elucidate the choice of surgery technique in similar patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: To compare abdominal and laparoscopic techniques of hysterectomy in terms of the surgery-induced trauma with measuring serum Pentraxin-3 (PTX3) level and neutrophil to lymphocyte ratio (NLR). Materials and Methods: In this study, preoperative and postoperative blood samples were used to compare the change at the level of PTX-3 and NLR in order to evaluate the inflammatory response in 40 patients, of whom, 20 had experienced Total Laparoscopic Hysterectomy (TLH) + Bilateral SalpingoOophorectomy (BSO) and 20 had experienced Total Abdominal Hysterectomy (TAH + BSO). Results: Based on our comparison, change in PTX-3 level in TLH+BSO group 4.5 ng/mL (0.3-18.6) was slightly higher than that of TAH+BSO group 3.0 ng/mL (0.0- 18.1), but the difference was not statistically significant (p =0.429). Likewise, the increase in the NLR in TLH+BSO group 3.5 (1.2-19.4) was slightly higher than that of TAH+BSO group 2.8 (-0.3-8.8), but not to a statistically significant extent (p = 0.114). Conclusion: When we use the inflammatory markers of PTX-3 and NLR, there was no significant difference between the two surgery techniques in terms of degree of tissue trauma. Further studies conducted with inflammatory markers other than PTX-3 and NLR are required to elucidate the choice of surgery technique in similar patients.

Abstract

Amaç: Pentraxin-3 (PTX-3) seviyesi ve nötrofil/lenfosit oranını ölçerek, cerrahi işlemin neden olduğu doku travması bakımından abdominal ve laparoskopik histerektominin karşılaştırılması. Materyal ve Metod: 20 Total laparoskopikhisterektomi + bilateral salpingoooferektomi (TLH+BSO) ve 20 total abdominal histerektomi + bilateral salpingoooferektomi (TAH + BSO) olmak üzere toplam 40 hasta çalışmaya dahil edildi. Tüm hastalardan operasyon öncesi ve sonrası dönemde kan örnekleri toplanarak Pentraxin-3 (PTX-3) seviyesi ve nötrofil/ lenfosit oranı belirlendi. Elde edilen veriler ile iki grup arasında karşılaştırmalı analizler yapıldı. Bulgular: Yaptığımız analizlerin sonucunda, PTX-3 seviyesindeki değişim TLH+BSO grubunda (4.5 ng/mL (0.3-18.6)) TAH+BSO grubuna göre (3.0 ng/mL (0.0-18.1)) istatistiksel anlam olmamasına rağmen hafif yüksek bulunmuştur (p =0.429). Benzer şekilde, nötrofil/ lenfosit oranındaki artış TLH+BSO grubunda (3.5 (1.2-19.4)) TAH+BSO grubuna göre (2.8 (-0.3-8.8)) )) istatistiksel anlam olmamasına rağmen hafif yüksek bulunmuştur (p = 0.114). Sonuç: İnflamatuar belirteçler olan PTX-3 ve nötrofil/ lenfosit oranı incelendiğinide, iki cerrahi teknik arasında doku travma dereceleri bakımından anlamlı fark gözlenmemiştir. İleride yapılacak olan PTX-3 ve nötrofil/ lenfosit oranı dışındaki inflamatuar belirteçlerin değerlendirilmesi benzer hastalarda cerrahi teknik seçimini aydınlatmaya katkı sağlayacaktır.

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Bu Makaleye Atıf Yap

HANÇER, K., AKBABA, E., SEZGİN, B., TURHAN, N. Ö. (2020). Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 3, 356–363. https://ajindex.com/articles/219268

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