Dergiler / JAREM / 2020 / Cilt: 10 - Sayı: 1

Sitagliptin/Metformin Related Cutaneous Leukocytoclastic Vasculitis in a Patient with Type-2 Diabetes Mellitus

Tip-2 Diyabetik Bir Olguda Sitagliptin/Metformin İlişkili Kutanöz Lökositoklastik Vaskülit

Dergi
JAREM
Sayfa
97–99
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In this case report, our aim is to present a 70-year-old female patient with the diagnosis of type 2 diabetes mellitus, and metformin/sitagliptin-induced cutaneous leukocytoclastic vasculitis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Small vessel vasculitis is characterized by the involvement of arterioles, capillaries, and venules.
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Temel Bulgular & Veri:Drug-related vasculitis is seen in 7 to 21 days after the onset of the drug and systemic findings are usually absent.
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Sonuç & Katkı:In this case report, our aim is to present a 70-year-old female patient with the diagnosis of type 2 diabetes mellitus, and metformin/sitagliptin-induced cutaneous leukocytoclastic vasculitis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Small vessel vasculitis is characterized by the involvement of arterioles, capillaries, and venules. The most common cutaneous finding of small vessel vasculitis is palpable purpura, and urticaria, petechiae, erythema, vesicles, and pustules may also be seen. It may be related to malignancies, connective tissue diseases, infections, and drugs such as penicillin, sulphonamides, allopurinol, antithyroid drugs but it is often idiopathic. Drug-related vasculitis is seen in 7 to 21 days after the onset of the drug and systemic findings are usually absent. Both metformin and sitagliptin are frequently used in the treatment of diabetes. However, skin reactions to these drugs are rare. In this case report, our aim is to present a 70-year-old female patient with the diagnosis of type 2 diabetes mellitus, and metformin/sitagliptin-induced cutaneous leukocytoclastic vasculitis.

Abstract

Küçük damar vaskülitleri, arteriyol, kapiller ve venüllerin tutulumu ile karakterizedir. Küçük damar vaskülitlerinin en yaygın bulgusu palpabl purpura olup, ürtiker, peteşi, eritem, vezikül ve püstül de görülebilir. Maligniteler, bağ dokusu hastalıkları, enfeksiyonlar ve penisilin, sülfonamidler, allopurinol, antitiroid gibi ilaçlarla ilişkili olabilir, ancak genellikle idiyopatiktir. İlaç ilişkili vaskülit genellikle ilacın başlanmasından 7-21 gün sonra görülmektedir. Hem metformin hem de sitagliptin tip 2 diyabet tedavisinde sıklıkla kullanılmaktadır. Ancak bu ilaçlara karşı deri reaksiyonları nadirendir. Biz burada, tip 2 diabetes mellitus tanılı 70 yaşında bir kadın hastada gelişen metformin/sitagliptin ilişkili kütanöz lökositoklastik vasküliti sunmayı amaçladık.

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Bu Makaleye Atıf Yap

SARGIN, G., KÖSE, R., ŞENTÜRK, T. (2020). Sitagliptin/Metformin Related Cutaneous Leukocytoclastic Vasculitis in a Patient with Type-2 Diabetes Mellitus. JAREM, Cilt: 10 - Sayı: 1, 97–99. https://ajindex.com/articles/217226

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Kaynakça (10)

  1. Chung L, Fiorentino D. Cutaneous vasculitis. Orphanet encyclopedia 2005; 1-18
  2. Ünübol M, Ceyhan C, Şentürk T, Tataroğlu C. Furosemide-induced cutaneous leucocytoclastic vasculitis: Case report. Turkiye Klinikleri 2011; 23: 79-82
  3. Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49: 2564-71
  4. Williams-Herman D, Engel SS, Round E, Johnson J, Golm GT, Guo H, et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes. BMC Endocr Disord 2010; 10:7
  5. Karagiannis T, Boura P, Tsapas A. Safety of dipeptidyl peptidase 4 inhibitors: a perspective review. Ther Adv Drug Saf 2014; 5: 138-46
  6. Nakatani K, Kurose T, Hyo T, Watanabe K, Yabe D, Kawamoto T, et al. Drug-induced generalized skin eruption in a diabetes mellitus patient receiving a dipeptidyl peptidase-4 inhibitor plus metformin. Diabetes Ther 2012; 3: 14
  7. Badr D, Kurban M, Abbas O. Metformin in dermatology: an overview. J Eur Acad Dermatol Venereol 2013; 27: 1329-35
  8. Ben Salem C, Hmouda H, Slim R, Denguezli M, Belajouza C, Bouraoui K. Rare case of metformin-induced leukocytoclastic vasculitis. Ann Pharmacother 2006; 40: 1685-7
  9. Attaway A, Mersfelder TL, Vaishnav S, Baker JK. Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature. J Dermatol Case Rep 2014; 8: 24-8
  10. Uçan B, Topaloğlu O, Önder E, Çakal E, Karbek E, Öztürk Ünsal B, et al. Sitagliptin Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report. Ortadogu Medıcal Journal 2012; 4: 199-201.