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Dergiler / Acta Orthopaedica et Traumatologica Turcica / 2015 / Cilt: 49 - Sayı: 3

Early surgery is feasible in patients with hip fractures who are on clopidogrel therapy

SİNAN ZEHİR
Regayip ZEHİR
Taner SARAK
Sayfa
249–254
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Surgery should not be postponed in hip fracture patients using clopidogrel.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Timing of surgery in hip fracture patients using antiplatelet agents is a controversial issue.
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Temel Bulgular & Veri:Methods: Elderly patients with femoral neck fractures who underwent open surgery between 2009 and 2014 were evaluated.
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Sonuç & Katkı:Conclusion: Surgery should not be postponed in hip fracture patients using clopidogrel.
🔬Tür:Araştırma Makalesi
📍Kapsam:2009 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Timing of surgery in hip fracture patients using antiplatelet agents is a controversial issue. Clopidogrel is an antiplatelet drug widely used in the treatment of many diseases. In this study, we aimed to investigate the outcomes of early surgery in hip fracture patients using clopidogrel. Methods: Elderly patients with femoral neck fractures who underwent open surgery between 2009 and 2014 were evaluated. Two hundred and eleven patients were included in the study. Patients were separated into 3 groups. Group 1 was constituted of patients using clopidogrel who had been operated on within 48 h after admission (n=74), Group 2 was constituted of patients using clopidogrel who had been operated on after the fifth day of admission (n=55), and Group 3 was constituted of patients not using clopidogrel who had been operated on within 48 h after admission (n=83). Length of hospital stay, amount of blood transfusion, rate of complication, and mortality rate were assessed for comparison of groups. Results: Age, sex, preoperative hemoglobin values, and ASA scores were not different between the groups. Amount of blood transfusions was higher in Group 1 (p=0.023). Duration of hospital stay was longer in Group 2 (p<0.01), as was complication rate (25.4%) (p<0.01). Mortality within 30 days and within the first 3 months post-surgery was significantly higher in Group 2 (p=0.031, p<0.01; respectively). Conclusion: Surgery should not be postponed in hip fracture patients using clopidogrel.

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Bu Makaleye Atıf Yap

ZEHİR, S., ZEHİR, R., SARAK, T. (2015). Early surgery is feasible in patients with hip fractures who are on clopidogrel therapy. Acta Orthopaedica et Traumatologica Turcica, Cilt: 49 - Sayı: 3, 249–254. https://ajindex.com/articles/215437

Kaynakça (15)

  1. Kannus P, Parkkari J, Sievänen H, Heinonen A, Vuori I, Järvinen M. Epidemiology of hip fractures. Bone 1996;18(1 Suppl):57–63
  2. Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, et al. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 2010;152(6):380–90
  3. Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth 2008;55:146–54
  4. Bhatt DL, Bertrand ME, Berger PB, L’Allier PL, Moussa I, Moses JW, et al. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting. J Am Coll Cardiol 2002;39:9–14
  5. Leong JY, Baker RA, Shah PJ, Cherian VK, Knight JL. Clopidogrel and bleeding after coronary artery bypass graft surgery. Ann Thorac Surg 2005;80:928–33
  6. Stone DH, Goodney PP, Schanzer A, Nolan BW, Adams JE, Powell RJ, et al. Clopidogrel is not associated with major bleeding complications during peripheral arterial surgery. J Vasc Surg 2011;54:779–84
  7. Steele MJ, Fox JS, Fletcher JP, Grigg LE, Bell G. Clopidogrel dilemma for orthopaedic surgeons. ANZ J Surg 2011;81:774–84
  8. Wordsworth DR, Halsey T, Griffiths R, Parker MJ. Clopidogrel has no effect on mortality from hip fracture. Injury 2013;44:743–6
  9. Cruden NL, Harding SA, Flapan AD, Graham C, Wild SH, Slack R, et al. Previous coronary stent implantation and cardiac events in patients undergoing noncardiac surgery. Circ Cardiovasc Interv 2010;3:236–42
  10. Leong JY, Baker RA, Shah PJ, Cherian VK, Knight JL. Clopidogrel and bleeding after coronary artery bypass graft surgery. Ann Thorac Surg 2005;80:928–33
  11. Feit F, Voeltz MD, Attubato MJ, Lincoff AM, Chew DP, Bittl JA, et al. Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 Trial. Am J Cardiol 2007;100:1364–9
  12. Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, et al. Guidelines on myocardial revascularization. Eur Heart J 2010;31:2501–55
  13. Zuckerman JD. Hip fracture. N Engl J Med 1996;334:1519–25
  14. Simunovic N, Devereaux PJ, Sprague S, Guyatt GH, Schemitsch E, Debeer J, et al. Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. CMAJ 2010;182:1609–16
  15. Orosz GM, Magaziner J, Hannan EL, Morrison RS, Koval K, Gilbert M, et al. Association of timing of surgery for h