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Dergiler / Acta Orthopaedica et Traumatologica Turcica / 2015 / Cilt: 49 - Sayı: 3

The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)

MURAT SONGÜR
ERCAN ŞAHİN
Tuğcan DEMİR
MAHMUT KALEM
GÜLNUR TAKE KAPLANOĞLU
Necdet Şükrü ALTUN
Sayfa
311–318
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Equine-derived BPE was found to be successful for treating cavitary bone defects not requiring scaffold use.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Bone protein extract (BPE) usually requires a carrier or a scaffold for implantation.
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Temel Bulgular & Veri:Bone defects of 6-mm diameter and 10–12-mm depth were created in the femoral condyles.
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Sonuç & Katkı:Equine-derived BPE was found to be successful for treating cavitary bone defects not requiring scaffold use.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Bone protein extract (BPE) usually requires a carrier or a scaffold for implantation. We aimed to compare the effect of equine-derived BPE, an osteoinductive agent composed of a high amount of type-I collagen and other bone proteins (Colloss-E), with that of human demineralized bone matrix (DBM) for treating cavitary bone defects not requiring scaffold use. Methods: Rabbit distal femoral condyle was used as a stable cavitary bone defect model. Bone defects of 6-mm diameter and 10–12-mm depth were created in the femoral condyles. Rabbits were assigned into the equine-derived BPE (BPE) , human-derived DBM (DBM), and control (C) groups. Approximately 20 mg of BPE was implanted into the defect in the equine-derived BPE group (n=6), whereas 0.3 cc of DBM was implanted in the DBM group (n=6). Defects were left empty in the C group (n=6). The defect area was histologically examined after 6 weeks. Results: There were no instances of macroscopic defect collapse or failure. Histopathological examination revealed that the BPE group had better scores (statistically significant) than both the other groups in terms of quality of union. The BPE group also had higher scores than the DBM group in terms of graft incorporation and new-bone formation. Conclusion: The current study revealed results consistent with those of the previous studies concerning BPEs. Equine-derived BPE was found to be successful for treating cavitary bone defects not requiring scaffold use.

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Bu Makaleye Atıf Yap

SONGÜR, M., ŞAHİN, E., DEMİR, T., KALEM, M., KAPLANOĞLU, G. T., ALTUN, N. Ş. (2015). The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica, Cilt: 49 - Sayı: 3, 311–318. https://ajindex.com/articles/213156

Kaynakça (15)

  1. Li H, Zou X, Woo C, Ding M, Lind M, Bünger C. Experimental anterior lumbar interbody fusion with an osteoinductive bovine bone collagen extract. Spine (Phila Pa 1976) 2005;30:890–6
  2. Walboomers XF, Jansen JA. Bone tissue induction, using a COLLOSS-filled titanium fibre mesh-scaffolding material. Biomaterials 2005;26:4779–85
  3. Huffer WE, Benedict JJ, Rettenmaier R, Briest A. Osteoinduction with COLLOSS, COLLOSS E, and GFm. Adv Exp Med Biol 2006;585:87–100
  4. Mizuno M, Fujisawa R, Kuboki Y. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction. J Cell Physiol 2000;184:207–13
  5. Mundy GR. Osteoblasts, bone formation and mineralization. In: Fogelman I, ed. Bone Remodeling and Its Disorders. London: Maetin Dunitz 1995:17–38
  6. Bertagnoli R. Osteoinductive bone regeneration substance Colloss in spinal fusion. Eur Spine J 2002;11:189–90
  7. Boden SD, Schimandle JH, Hutton WC. Lumbar intertransverse-process spinal arthrodesis with use of a bovine bone-derived osteoinductive protein. A preliminary report. J Bone Joint Surg Am 1995;77:1404–17
  8. Schlegel KA, Donath K, Rupprecht S, Falk S, Zimmermann R, Felszeghy E, et al. De novo bone formation using bovine collagen and platelet-rich plasma. Biomaterials 2004;25:5387–93
  9. Lasmézas CI. The transmissible spongiform encephalopathies. Rev Sci Tech 2003;22:23–36
  10. Williams ES, Miller MW. Transmissible spongiform encephalopathies in non-domestic animals: origin, transmission and risk factors. Rev Sci Tech 2003;22:145–56
  11. El-Sabban ME, El-Khoury H, Hamdan-Khalil R, SindetPedersen S, Bazarbachi A. Xenogenic bone matrix extracts induce osteoblastic differentiation of human bone marrowderived mesenchymal stem cells. Regen Med 2007;2:383– 90
  12. Nienhuijs ME, Walboomers XF, Merkx MA, Stoelinga PJ, Jansen JA. Bone-like tissue formation using an equine COLLOSS E-filled titanium scaffolding material. Biomaterials 2006;27:3109–14
  13. Li H, Springer M, Zou X, Briest A, Bünger C. Ectopic bone induction by equine bone protein extract. Adv Exp Med Biol 2006;585:393–402
  14. Nienhuijs ME, Walboomers XF, Gelinsky M, Stoelinga PJ, Jansen JA. The evaluation of mineralized collagen as a carrier for the osteoinductive material COLLOSS(®)E, in vivo. Tissue Eng Part A. 2011;17:1683–90
  15. Salkeld SL, Patron LP, Barrack RL, Cook SD. The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone.