Genetic Properties of Copy Number Variations in Some Pakistani Cattle Breeds

Amaç & Hipotez:A copy number variation (CNV) is information of DNA segment containing deletion, duplication or insertion exist within diverse populations.

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Temel Bulgular & Veri:This study detected 53 CNVs regions that overlapped with immune response, body size and parasitic resistance traits in Pakistani cattle breeds.

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Sonuç & Katkı:Keywords: Copy number variation, Diversity, Traits, Breed, Pakistan

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

A copy number variation (CNV) is information of DNA segment containing deletion, duplication or insertion exist within diverse populations. This study detected 53 CNVs regions that overlapped with immune response, body size and parasitic resistance traits in Pakistani cattle breeds. This study characterized genetic diversity and provides lineage differentiated CNVs in these indigenous cattle breeds. Keywords: Copy number variation, Diversity, Traits, Breed, Pakistan

Abstract

Kopya sayısı değişikliği (CNV) farklı popülasyonlar içerisinde delesyon, duplikasyon ve insersiyonları içeren DNA segmentlerinin bilgisidir. Bu çalışma ile Pakistan sığır ırkları arasında bağışıklık yanıtı, vücut boyutu ve parazit direnci özelliklerini içeren 53 CNV tespit edildi. Bu çalışma; belirtilen yerel sığır ırkları arasında genetik çeşitliliği göstermiş ve hat farklı CNV’leri belirlemiştir.

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Bu Makaleye Atıf Yap

MUSTAFA, H., KHAN, W. A., EUISOO, K., KUTHU, Z. H., AJMAL, A., ALI, A., JAVED, K., SONSTEGARD, T. S. (2018). Genetic Properties of Copy Number Variations in Some Pakistani Cattle Breeds. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 24 - Sayı: 4, 599–602. https://ajindex.com/articles/212775

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Kaynakça (4)

Öner Y, Yılmaz O, Okut H, Ata N, Yılmazbaş-Mecitoğlu G, Keskin A: Associations between GH, PRL, STAT5A, OPN, PIT-1, LEP and FGF2 polymorphisms and fertility in Holstein-Friesian heifers. Kafkas Univ Vet Fak Derg, 23 (4): 527-534, 2017. DOI: 10.9775/kvfd.2016.17192 Liu GE, Hou Y, Zhu B, Cardone MF, Jiang L, Cellamare A, Mitra A, Alexander LJ, Coutinho LL, Dell’Aquila ME, Gasbarre LC, Lacalandra G, Li RW, Matukumalli LK, Nonneman D, Regitano LC, Smith TP, Song J, Sonstegard TS, Van Tassell CP, Ventura M, Eichler EE, McDaneld TG, Keele JW: Analysis of copy number variations among diverse cattle breeds. Genome Res, 20, 693-703, 2010. DOI: 10.1101/gr.105403.110 Salomon-Torres R, Gonzalez-Vizcarra VM, Medina-Basulto GE, Montano-Gomez MF, Mahadevan P, Yaurima-Basaldua VH, VillaAngulo C, Villa-Angulo R: Genome-wide identification of copy number variations in Holstein cattle from Baja California, Mexico, using highdensity SNP genotyping arrays. Genet Mol Res, 14, 11848-11859, 2015. DOI: 10.4238/2015.October.2.18 Jiang L, Jiang J, Yang J, Liu X, Wang J, Wang H, Ding X, Liu J, Zhang Q: Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins. BMC Genomics, 14, 131, 2013. DOI: 10.1186/1471-2164-14-131
Zhang Q, Ma Y, Wang X, Zhang Y, Zhao X: Identification of copy number variations in Qinchuan cattle using BovineHD Genotyping Beadchip array. Mol Genet Genomics, 290, 319-327, 2015. DOI: 10.1007/ s00438-014-0923-4
Zhang X, Wang K, Wang L, Yang Y, Ni Z, Xie X, Shao X, Han J, Wan D, Qiu Q: Genome-wide patterns of copy number variation in the Chinese yak genome. BMC Genomics, 17, 379, 2016. DOI: 10.1186/s12864-016-2702-6
Xu L, Hou Y, Bickhart DM, Zhou Y, Hay el HA, Song J, Sonstegard TS, Van Tassell CP, Liu GE: Population-genetic properties of differentiated copy number variations in cattle. Sci Rep, 6, 23161, 2016. DOI: 10.1038/ srep23161 da Silva VH, de Almeida Regitano LC, Geistlinger L, Pertille F, Giachetto PF, Brassaloti RA, Morosini NS, Zimmer R, Coutinho LL: Genome-Wide detection of CNVs and their association with meat tenderness in Nelore cattle. PLoS One, 11, e0157711, 2016. DOI: 10.1371/ journal.pone.0157711 Bickhart DM, Xu L, Hutchison JL, Cole JB, Null DJ, Schroeder SG, Song J, Garcia JF, Sonstegard TS, Van Tassell CP, Schnabel RD, Taylor JF, Lewin HA, Liu GE: Diversity and population-genetic properties of copy number variations and multi-copy genes in cattle. DNA Res, 23, 253- 262, 2016. DOI: 10.1093/dnares/dsw01