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Dergiler / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 1

Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis

Dunja MIHAJLOVIC
Dajana LENDAK
Gorana MITIC
Tatjana CEBOVIC
Biljana DRASKOVIC
Aleksandra NOVAKOV
Snezana BRKIC
Sayfa
93–98
Yayın Tarihi
2015-03-15
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Hemostasis-related parameters have a significant impact on severity and outcome in sepsis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system.
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Temel Bulgular & Veri:Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset.
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Sonuç & Katkı:Conclusion: Hemostasis-related parameters have a significant impact on severity and outcome in sepsis.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Sepsis · hemostasis · multiple organ failure

Özet

Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis-related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Materials and methods: Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences between groups of septic patients were assessed by Mann-Whitney U test and Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors. Results: Prolonged aPTT and PT with higher D-dimer concentrations in patients with sepsis are associated with more severe forms of the disease. aPTT was prolonged in nonsurvivors, while platelet count and fibrinogen levels were higher in survivors. Platelet count and aPTT ratio are independent predictors of fatal outcome in our logistic regression model. Conclusion: Hemostasis-related parameters have a significant impact on severity and outcome in sepsis.

Abstract

Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis-related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Materials and methods: Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences between groups of septic patients were assessed by Mann-Whitney U test and Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors. Results: Prolonged aPTT and PT with higher D-dimer concentrations in patients with sepsis are associated with more severe forms of the disease. aPTT was prolonged in nonsurvivors, while platelet count and fibrinogen levels were higher in survivors. Platelet count and aPTT ratio are independent predictors of fatal outcome in our logistic regression model. Conclusion: Hemostasis-related parameters have a significant impact on severity and outcome in sepsis.

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Bu Makaleye Atıf Yap

MIHAJLOVIC, D., LENDAK, D., MITIC, G., CEBOVIC, T., DRASKOVIC, B., NOVAKOV, A., BRKIC, S. (2015). Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 1, 93–98. https://ajindex.com/articles/204874

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Kaynakça (11)

  1. Dombrovskiy VY, Martin AA, Sunderram J Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007; 35: 1244–1250.
  2. Charalampos P, Vincent JL. Sepsis biomarkers: a review. Crit Care 2010; 14: R15. Breslow M, Badawi O. Severity scoring in the critically ill. Part 1-Interpretation and accuracy of outcome prediction scoring systems. Chest 2012; 141: 245–252.
  3. Giannoni C, Chelazzi C, Villa G, Raffaele De Gaudio A. Organ dysfunction scores in ICU. Trends in Anaesthesia and Critical Care 2013; 3: 89–96.
  4. Schouten M, Wiersinga WJ, Levi M. Inflammation, endothelium, and coagulation in sepsis. J Leukocyte Biol 2008; 83: 536–545.
  5. Totan M, Dilber C, Albayrak D. Protein C, protein S and antithrombin III levels in a rabbit sepsis model. Turk J Med Sci 1999; 29: 389–391.
  6. Yıldız BD, Yorgancı K. Current trends and future implications in sepsis treatment. Turk J Med Sci 2008; 38: 501–510.
  7. Battah AA, El Gohary TS, Ashraf M. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Journal of American Science 2010; 6: 382–388. Levi M. The coagulant response in sepsis and inflammation. Hämostaseologie 2011; 1: 10–16. Levi M, van der Poll T, Büller HR. Bidirectional relation between inflammation and coagulation. Circulation 2004; 109: 2698–2704. Levi M. Coagulation. In: Cavaillon JM, Adire C, editors. Sepsis and Non-Infectious Systemic Inflammation. From Biology to Critical Care. Weinheim, Germany: Wiley-VCH Verlag; 2009. pp. 251–278.
  8. Lissalde-Lavigne G, Combescure C, Muller L, Bengler C, Raillard A, Lefrant JY, Gris JC. Simple coagulation tests improve survival prediction in patients with septic shock. J Thromb Haemost 2008; 6: 645–645.
  9. Bone R, Balk R, Cerra F, Dellinger R, Fein A, Knaus W, Schein R, Sibbald W. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644–1655.
  10. Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D, Cohen J, Opal S, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250–1256.
  11. Hamzaoui O, Carlet J. Organ dysfunctions during severe sepsis and septic-like syndromes: epidemiology, classification, and mechanisms. In: Cavaillon JM, Adire C, editors. Seps