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Dergiler / Turkish Journal of Biology / 2020 / Cilt: 44 - Sayı: 4

Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model

Mehmet OZANSOY
Mehmet Ozgen ALTİNTAS
Muzaffer Beyza OZANSOY
Necmeddin GUNAY
Ertugrul KİLİC
Ulkan KİLİC
Sayfa
208–214
Yayın Tarihi
2020-08-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Boron is a naturally occurring trace element found in organic and inorganic complexes.
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Temel Bulgular & Veri:Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals.
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Sonuç & Katkı:This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Boron · neuronal survival · amyloid-beta

Abstract

Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these 2 compounds increase the survival of the SH-SY5Y cells. Furthermore, boron in these 2 forms increases the expression of Sirt1, which has protective functions against cellular stress. The compounds also change the expressions of GSK-3 alpha/beta; by doing so, boron may contribute to the stimulation of intracellular prosurvival pathways. This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.

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Bu Makaleye Atıf Yap

OZANSOY, M., ALTİNTAS, M. O., OZANSOY, M. B., GUNAY, N., KİLİC, E., KİLİC, U. (2020). Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model. Turkish Journal of Biology, Cilt: 44 - Sayı: 4, 208–214. https://ajindex.com/articles/201119

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Kaynakça (2)

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