Dergiler / Journal of Urological Surgery / 2018 / Cilt: 5 - Sayı: 3

Gender-related Differences in Surgically Treated Patients with Renal Cell Carcinoma

Cerrahi Olarak Tedavi Edilen Böbrek Tümörü Hastalarının Cinsiyete Özgü Farklılıkları

Sayfa
170–173
DOI
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The results were similar with other European studies.

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Amaç & Hipotez:Objective: The aim of the study was to investigate gender-specific differences in the Turkish patients with renal cell carcinoma (RCC) undergoing radical or nephron-sparing nephrectomy and compare the results with those in other regions.
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Temel Bulgular & Veri:Materials and Methods: Data of 76 patients, who were clinically diagnosed with RCC and underwent radical or nephron-sparing nephrectomy from January 2011 to August 2017, were retrospectively evaluated.
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Sonuç & Katkı:The results were similar with other European studies.
🔬Tür:Araştırma Makalesi
📍Kapsam:2011 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The aim of the study was to investigate gender-specific differences in the Turkish patients with renal cell carcinoma (RCC) undergoing radical or nephron-sparing nephrectomy and compare the results with those in other regions. Materials and Methods: Data of 76 patients, who were clinically diagnosed with RCC and underwent radical or nephron-sparing nephrectomy from January 2011 to August 2017, were retrospectively evaluated. Age and gender of the patients and the size, histological type, grade and pathological stage of the tumors were recorded. A chi-square test was used for comparing categorical variables, whereas the Student’s t-test was used for the same purpose in the continuous variables. Results: Of the 67 patients, 39 (58.2%) were male and 28 (41.8%) were female; male-to-female ratio was 3:2. The mean age of the male and female patients was 63.4±11.7 years and 59.3±14.3 years, respectively and the mean tumor size was 5.7 and 5.3 cm, respectively. There were differences in mean age, tumor size and Fuhrman grade, however, none of them reached the level of statistical significance. Twenty four of the male and 25 of the female patients had low-stage, 15 of the male and 3 of the female patients had high-stage disease. Thus, the male patients had higher stage disease than the female patients and the difference was statistically significant (p=0.011). Conclusion: Turkish women with RCC had significantly lower stage disease than Turkish men, although grade and size of the tumor did not present a statistically significant difference. The results were similar with other European studies.

Abstract

Amaç: Çalışmamızın amacı, radikal ya da nefron koruyucu cerrahi ile tedavi edilmiş renal hücreli karsinomlu (RHK) hastalarımızın cinsiyete özgü farklılıklarını değerlendirmek ve bunu diğer bölgeler ile karşılaştırmaktır. Gereç ve Yöntem: Ocak 2011 ile Ağustos 2017 arasında klinik olarak RHK tanısı almış ve radikal veya nefron koruyucu nefrektomi operasyonu geçirmiş olan 76 hastanın verileri retrospektif olarak gözden geçirildi. Hastaların yaşları ve cinsiyetleri ile tümörlerinin boyutu, histolojik tipi, derecesi ve patolojik evreleri bulundu. Kategorik değişkenlerin değerlendirilmesinde ki-kare testi, sürekli değişkenlerin değerlendirilmesinde ise Student’s t-testi kullandı. Bulgular: Altmış yedi hastanın 39’u (%58,2) erkek, 28’i (%41,8) ise kadındı ve erkek/kadın oranı 3:2 idi. Erkeklerin ortalama yaşı 63,4±11,7; kadınların ise 59,3±14,3 yıl idi. Ortalama tümör boyutu erkeklerde 5,7; kadınlarda ise 5,3 cm idi. Ortalama yaş, tümör boyutu ve Fuhrman derecesinde fark saptanmasına rağmen anlamlı seviyeye ulaşmadı. Erkeklerin 24’ü düşük, 15’i yüksek; kadınların ise 25’i düşük, 3’ü yüksek evreli hastalığa sahipti. Yani erkekler istatistiksel olarak anlamlı şekilde kadınlardan daha yüksek evreli hastalığa sahipti (p=0,011). Sonuç: Sonuç olarak, kadın popülasyonumuz erkeklere göre anlamlı şekilde daha düşük evreli tümöre sahip olmasına rağmen, tümörlerin derecesi ve boyutları anlamlı bir farklılık göstermedi. Sonuçlarımız Avrupa çalışmalarıyla uyumlu bulundu.

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Bu Makaleye Atıf Yap

AKARKEN, İ., DERE, Y., TARHAN, H., DELİKTAŞ, H., ŞAHİN, H. (2018). Gender-related Differences in Surgically Treated Patients with Renal Cell Carcinoma. Journal of Urological Surgery, Cilt: 5 - Sayı: 3, 170–173. https://ajindex.com/articles/199292

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Kaynakça (13)

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:359-386.
  2. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. 2004. https:// www.iarc.fr/en/publications/pdfs-online/pat-gen/bb7/BB7.pdf. Mathew A, Devesa SS, Fraumeni JF Jr, Chow WH. Global increases in kidney cancer incidence, 1973-1992. Eur J Cancer Prev 2002;11:171-178.
  3. Silverberg E, Holleb AI. Cancer statistics, 1971. CA Cancer J Clin 1971;21:13- 31. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-2917.
  4. Kabat GC, Silvera SAN, Miller AB, Rohan TE. A cohort study of reproductive and hormonal factors and renal cell cancer risk in women. Br J Cancer 2007;96:845-849.
  5. McCauley LR, Beckham CJ, Hunter TB, Nguyen MM. Gender and Renal Cancer: Do Variations in Clinical Presentation and Imaging Patterns Explain Observed Differences Between Males and Females? Urology 2010;76:536-540. Edge SB; American Joint Committee on Cancer. AJCC Cancer Staging Manual. In: Bryd RD, Compton CC, Fritz GA. Springer, 2010.
  6. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655-663.
  7. Aron M, Nguyen MM, Stein RJ, Gill IS. Impact of Gender in Renal Cell Carcinoma: An Analysis of the SEER Database. Eur Urol 2008;54:133-142.
  8. Stafford HS, Saltzstein SL, Shimasaki S, Sanders C, Downs TM, Sadler GR. Racial/Ethnic and Gender Disparities in Renal Cell Carcinoma Incidence and Survival. J Urol 2008;179:1704-1708.
  9. Woldrich JM, Mallin K, Ritchey J, Carroll PR, Kane CJ. Sex Differences in Renal Cell Cancer Presentation and Survival: An Analysis of the National Cancer Database, 1993-2004. J Urol 2008;179:1709-1713.
  10. Schrader AJ, Sevinc S, Olbert PJ, Hegele A, Varga Z, Hofmann R. Genderspecific characteristics and survival of renal cell carcinoma. Urologe 2008;47:1182-1186.
  11. Hew MN, Zonneveld R, Kümmerlin IP, Opondo D, de la Rosette JJ, Laguna MP. Age and Gender Related Differences in Renal Cell Carcinoma in a European Cohort. J Urol 2012;188:33-38.
  12. Lee JE, Hankinson SE, Cho E. Reproductive factors and risk of renal cell cancer: the Nurses’ Health Study. Am J Epidemiol 2009;169:1243-1250.
  13. Lee S, Jeon HG, Kwak C, Kim HH, Byun SS, Lee SE, Lee