Dergiler / Eastern Journal of Medicine / 2018 / Cilt: 23 - Sayı: 3

Evaluation of hematologic and biochemical parameters in patients with early stage uterine malignancy receiving radiotherapy

Sayfa
146–152
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The effect of radiotheraphy seen as lower values of hemoglobin and hematocrite in endometrial malignancy patients resolved and become normal after three months of the radiotherapy.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Surgery is the primary choice of treatment for this disorder.
📊
Temel Bulgular & Veri:The aim of this study is to define the statistical difference of hemogram, transaminases, kidney function tests and electrolyte changes in patients before starting radiotherapy, the end of radiotherapy, with the onset of acute side effects, and three months after finishing radiotherapy with the onset of chronic side effects. 18 patients with early stage endometrial malignancy attending to Adana Numune Training and Research Hospital have been included.
💡
Sonuç & Katkı:The effect of radiotheraphy seen as lower values of hemoglobin and hematocrite in endometrial malignancy patients resolved and become normal after three months of the radiotherapy.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Surgery is the primary choice of treatment for this disorder. Radiotherapy is an important step of treatment in this cancer after surgery due to the stage of the disease. Lack of prospective randomised data for survival limits the use of adjuvant radiotherapy. Hovewer adjuvant radiotherapy is suggested for high risk patients to reduce locoregional recurrence. The aim of this study is to define the statistical difference of hemogram, transaminases, kidney function tests and electrolyte changes in patients before starting radiotherapy, the end of radiotherapy, with the onset of acute side effects, and three months after finishing radiotherapy with the onset of chronic side effects. 18 patients with early stage endometrial malignancy attending to Adana Numune Training and Research Hospital have been included. This study has assessed the changes in hemogram, blood transaminases, urea, creatinin and electrolyte values of patients before radiotherapy, at the last week of radiotherapy and three months after radiotherapy. The values were statistically significant for AST, Ca, LDH, urea, Hb and HTC values before treatment, at the end of the treatment and three months after treatment (p<0.05). The effect of radiotheraphy seen as lower values of hemoglobin and hematocrite in endometrial malignancy patients resolved and become normal after three months of the radiotherapy.

🔖

Bu Makaleye Atıf Yap

KARACA, F., MENTES, S., KESKİN, S. (2018). Evaluation of hematologic and biochemical parameters in patients with early stage uterine malignancy receiving radiotherapy. Eastern Journal of Medicine, Cilt: 23 - Sayı: 3, 146–152. https://ajindex.com/articles/198811

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (11)

  1. Karsten M, Margrit V, Richard VG. Hemoglobin levels during radiation therapy and their influence on local control and survival of patients with endometrial carcinoma. Oncol Rep 2004; 11: 711- 717. Dische S. Radiotherapy and anaemia--the clinical experience. Radiother Oncol 1991; 20: 35-40.
  2. Demetri GD, Kris M, Wade J, et al. Quality-oflife benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. Procrit study group. J Clin Oncol 1998; 16: 3412-3425. Cella D. Factors influencing quality of life in cancer patients: anemia and fatigue. Semin Oncol 1998; 25: 43-46.
  3. Vuthinun Achariyapota, Mongkol Benjapibal, Pattama Chaopotong. Prevalence and Incidence of Anemia in Thai Patients with Gynecologic Cancer. Asian Pacific J Cancer Prev 11: 1229- 1233. Agata Jodda, Bartosz Urban´ ski, Tomasz Piotrowski, Julian Malicki. Relations between doses cumulated in bone marrow and dose delivery techniques during radiation therapy of cervical and endometrial cancer. Physica Medica 2017; 36: 54-59.
  4. F.A. Eggink, C.H.Mom, D. Boll, et al. Compliance with adjuvant treatment guidelines in endometrial cancer: room for improvement in high risk patients. Gynecologic Oncology 2017; 146: 380-385.
  5. Kayaalp O, Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, sayfa 1522-1524, 2.cilt, 8.Basım, Hacettepe Taş Kitapçılık, Sıhhıye, Ankara.
  6. Leonard L. Gunderson, Joel E. Tepper. clınıcal radıatıon oncology. Fourth edıtıon. 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103- 2899. William H. McBride, H. Rodney Withers. Cancer Biology. Ed: Carlos A.Perez, Luther W.Brady, Edward C.Halperin, Rupert K.Schmidt-Ullrich. Principles and practice of radiation Oncology. 4th Edition, pp. 96-136, USA 2004.
  7. Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 2001; 18: 243-259.
  8. Barrett-Lee P, Bokemeyer C, Gascón P, et al Management of cancer-related anemia in patients with breast or gynecologic cancer: new insights based on results from theEuropean Cancer Anemia Survey. Oncologist 2005; 10: 743-757.
  9. Newman A, Katsaris J, Blendis LM, et al. Small intestinal injury in women who have had pelvic radiotherapy. Lancet 1973; 2: 1471-1473.
  10. Bloomer WD, Hellman S. Normal tissue responses to radiation therapy. N Engl J Med 1975; 293: 80-83.
  11. Klopp A, Smith BD, Alektiar K, et al. The role of postoperative radiation therapy for endometrial cancer: executive summary of a