Dergiler / Kocaeli Tıp Dergisi / 2019 / Cilt: 8 - Sayı: 2

Prognostic Efficacy of C-reactive Protein to Albumin Ratio in Patients with ST Elevation Myocardial Infarction Complicated by Cardiogenic Shock

Kardiyojenik Şok ile Komplike Olmuş ST Yükselmeli Miyokard Enfarktüslü Hastalarda C-reaktif Proteinin Albümin Oranına Prognostik Etkinliği

Sayfa
134–141
DOI
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DISCUSSION and CONCLUSION: The present study is the first to demonstrate that the CAR may have a prognostic value for the in-hospital mortality in patients with STEMI complicated by cardiogenic shock.

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Amaç & Hipotez:ABSTRACT INTRODUCTION: In this study, we aimed to investigate whether C-reactive protein (CRP) to albumin ratio (CAR), recently developed inflammation based risk index, has a prognostic value in patients with ST elevation myocardial infarction (STEMI) complicated by cardiogenic shock due to a pump failure.
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Temel Bulgular & Veri:METHODS: We retrospectively enrolled 79 consecutive STEMI patients who underwent a primary percutaneous coronary intervention and complicated by cardiogenic shock.
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Sonuç & Katkı:DISCUSSION and CONCLUSION: The present study is the first to demonstrate that the CAR may have a prognostic value for the in-hospital mortality in patients with STEMI complicated by cardiogenic shock.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

ABSTRACT INTRODUCTION: In this study, we aimed to investigate whether C-reactive protein (CRP) to albumin ratio (CAR), recently developed inflammation based risk index, has a prognostic value in patients with ST elevation myocardial infarction (STEMI) complicated by cardiogenic shock due to a pump failure. METHODS: We retrospectively enrolled 79 consecutive STEMI patients who underwent a primary percutaneous coronary intervention and complicated by cardiogenic shock. RESULTS: During the in-hospital course, 40 of the 79 patients (50.6%) died. The mean value of CAR was significantly higher in patients with non-survivors than those who survived (8.58 [4.68–12.25] vs. 4.67 [4.21–6.03]; p<0.001). A Cox multivariate regression analyses revealed that the CAR was an independent predictor of the in-hospital mortality (HR: 1.053, 95%CI: 1.006-1.101; p=0.027). KaplanMeier analysis showed that the patients with CAR≥8.4 had a significantly higher the incidence of death compared to those with CAR<8.4 (p<0.001). DISCUSSION and CONCLUSION: The present study is the first to demonstrate that the CAR may have a prognostic value for the in-hospital mortality in patients with STEMI complicated by cardiogenic shock.

Abstract

ÖZ GİRİŞ ve AMAÇ: Bu çalışmada, yakın zamanda geliştirilen enflamasyon dayalı risk indeksi olan C-reaktif proteinin (CRP) /Albümin oranının (CAR), pompa yetersizliğine bağlı kardiyojenik şok ile komplike olmuş ST yükselmeli miyokard enfarktüs hastalarında (STYME) prognostik bir değere sahip olup olmadığını araştırmayı amaçladık. YÖNTEM ve GEREÇLER: Primer perkutan koroner girişim uygulanmış ve kardiyojenik şok ile komplike olmuş 79 ardışık STYME hastası geriye dönük olarak çalışmaya alındı. BULGULAR: Hastane içi takip sırasında 79 hastanın 40'ı (% 50,6) öldü. Ortalama CAR değeri sağ kalımı olmayanlarda sağ kalanlarına göre anlamlı derecede yüksekti (8.58 [4.68–12.25] vs. 4.67 [4.21–6.03]; p <0.001). Çok değişkenli regresyon analizi, CAR'ın hastane içi mortalitenin bağımsız bir belirleyicisi olduğunu ortaya koydu (HR: 1.053, % 95 CI: 1.006-1.101; p = 0.027). Kaplan-Meier analizi, CAR ≥8.4 olan hastaların ölüm sıklığı CAR <8.4 olanlara göre anlamlı derecede yüksek olduğunu gösterdi (p <0.001). TARTIŞMA ve SONUÇ: Bu çalışma, kardiyojenik şok ile komplike olmuş STYME hastalarında CAR'ın hastane içi mortalite için prognostik bir değere sahip olduğunu gösteren ilk çalışmadır.

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Bu Makaleye Atıf Yap

ÇINAR, T., TANIK, V. O., BURAK, C., YESİN, M., KARABAĞ, Y., RENCÜZOĞULLARI, İ. (2019). Prognostic Efficacy of C-reactive Protein to Albumin Ratio in Patients with ST Elevation Myocardial Infarction Complicated by Cardiogenic Shock. Kocaeli Tıp Dergisi, Cilt: 8 - Sayı: 2, 134–141. https://ajindex.com/articles/198718

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Kaynakça (11)

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