The relation between Helicobacter pylori and symptomatic cholelithiasis

Conclusion: Although the presence of H. pylori in gallbladder was revealed, we are in need of further studies to demonstrate the relation between H. pylori and the formation of gallbladder stones.

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Amaç & Hipotez:Objective: The presence of Helicobacter pylori (H. pylori) in biliary tract has recently been discovered.

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Temel Bulgular & Veri:In this study, we aimed to demonstrate the relationship between H. pylori, gallbladder diseases and the upper gastrointestinal symptoms by investigating the presence of H. pylori in the mucosa of the gallbladder and stomach in patients operated for symptomatic cholelithiasis.

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Sonuç & Katkı:Conclusion: Although the presence of H. pylori in gallbladder was revealed, we are in need of further studies to demonstrate the relation between H. pylori and the formation of gallbladder stones.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The presence of Helicobacter pylori (H. pylori) in biliary tract has recently been discovered. In this study, we aimed to demonstrate the relationship between H. pylori, gallbladder diseases and the upper gastrointestinal symptoms by investigating the presence of H. pylori in the mucosa of the gallbladder and stomach in patients operated for symptomatic cholelithiasis. Methods: Hundred and five patients who underwent cholecystectomy for symptomatic cholelithiasis and upper gastrointestinal endoscopic procedure for dyspeptic symptoms were included to this study. Histopathology findings of endoscopic biopsy specimens of the upper gastrointestinal and cholecystectomy material were evaluated for the presence of H. pylori using immunohistochemical staining methods with toludine blue (T. blue) and Warthin starry stains (W. starry). Results: H. pylori was identified in the biopsy specimens excised from gallbladders of 28 (26.7%), and gastric mucosa of 37 (35.2%) patients. Any correlation between H. pylori positivities in the gastric mucosa and gallbladder specimens could not detected (p>0.05, r=0.051). H. pylori was also associated with any specific gallbladder pathology. Conclusion: Although the presence of H. pylori in gallbladder was revealed, we are in need of further studies to demonstrate the relation between H. pylori and the formation of gallbladder stones.

Abstract

Amaç: Helicobacter pylori’nin (H.pylori) safra yollarında varlığı henüz yeni saptanmıştır. Bu çalışmada, H. pylori ile safra kesesi hastalıkları ve üst gastrointestinal semptomlar arasındaki ilişkiyi, semptomatik kolelitiasis nedeniyle opere edilen hastaların safra kesesi ve mide mukozalarında H. pylori varlığını araştırarak ortaya koymayı amaçladık. Yöntem: Semptomatik kolelitiasis nedeniyle kolesistektomi uygulanan ve dispeptik semptomlar nedeniyle üst gastrointestinal endoskopik işlem yapılan 105 hasta çalışmaya dahil edildi. Üst gastrointestinal endoskopik biyopsi ve kolesistektomi patoloji spesimenleri H. pylori varlığı açısından Toludine blue (T. blue) ve Warthin starry (W. starry) ile immünohistikimyasal boyama yöntemleri kullanılarak araştırıldı. Bulgular: H. pylori 28 hastanın (%26,7) safra kesesi spesimenlerinde ve 37 hastanın (%35,2) mide mukozasında pozitif olarak bulunmuştur. Mide mukozası ve safra kesesi spesimenlerindeki H. pylori pozitifliği arasındaki ilişki araştırılmış ve ilişkili bulunmamıştır (p>0,05, r=0,051). H. pylori ayrıca hiçbir spesifik safra kesesi patolojisi ile de ilişkilendirilememiştir. Sonuç: Her ne kadar safra kesesinde H. pylori saptanmış olsa da, H. pylori ve safra kesesi taşları oluşumu arasındaki ilişkiyi ortaya koymak için daha ileri çalışmalara gereksinim vardır.

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Bu Makaleye Atıf Yap

ÇETİNDAĞ, Ö., BALCI, B., SERT, İ., EKMEKÇİ, S., DİNİZ, G., İPEKÇİ, F. (2018). The relation between Helicobacter pylori and symptomatic cholelithiasis. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 28 - Sayı: 3, 197–202. https://ajindex.com/articles/197623

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Kaynakça (10)

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