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AI InsightOn the other hand, the identification of the Lp(a) level in patients with psoriasis with cardiovascular diseases may be an appropriate diagnostic tool for the evaluation of atherosclerotic and vasoocclusive pathologies.
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Özet
Introduction: Psoriasis vulgaris (PV) was considered to be a chronic, recurrent skin disease, but it has been accepted as a chronic systemic inflammatory disease in recent years. Lipoprotein(a) (Lp(a)) is a lipoprotein that is synthesized in the liver and has a low-density lipoprotein (LDL)-like molecular structure consisting of phospholipids, cholesterol, and apolipoprotein B-100 derivative. Serum levels of Lp(a) are not affected by the amount of lipid incorporated into the diet and lifestyle changes. The aim of this study is to compare blood lipid and Lp(a) levels between the PV patient group and healthy control group and to investigate whether psoriasis creates a predisposition to atherosclerosis. Methods: Forty-four patients with clinical and/or histopathological diagnosis of chronic plaque-type PV and 48 healthy subjects were included in the study. Serum total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, serum LDL cholesterol, very low-density lipoprotein (VLDL) cholesterol, and serum Lp(a) levels were measured. Results: Total cholesterol, triglyceride, and HDL, LDL, and VLDL cholesterol levels were not statistically different between the psoriasis and healthy control groups (p=0.071, p=0.374, p=0.060, p=0.421, and p=0.759, respectively). Lp(a) levels were higher in the psoriasis group than in the healthy control group (p<0.001). Discussion and Conclusion: According to the results of our study, increased Lp(a) levels in patients with psoriasis may be more likely to induce atherosclerosis than those in the normal population. On the other hand, the identification of the Lp(a) level in patients with psoriasis with cardiovascular diseases may be an appropriate diagnostic tool for the evaluation of atherosclerotic and vasoocclusive pathologies.