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Dergiler / Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering / 2021 / Cilt: 22 - Sayı: 1

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Fatih Erdem BAŞTAN
Sayfa
10–22
Yayın Tarihi
2021-03-26
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Gelatin was released from the microspheres after immersion in the phosphate buffer saline (PBS) solution for 14 days.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications.
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Temel Bulgular & Veri:TG-DTA results showed that gelatin was evolved from the microspheres ~300 °C, and bare HA was stable up to 1400 °C.
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Sonuç & Katkı:Gelatin was released from the microspheres after immersion in the phosphate buffer saline (PBS) solution for 14 days.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Functionalized Hydroxyapatite · gelatin · spray drying

Abstract

In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a drug carrier system. The dissolution of the polymer in the physiological medium allows to release the drug in a controlled manner and also develop the cell-microsphere interactions. Gelatin functionalized HA microspheres and bare HA granules were produced by spray drying. The morphology, thermal properties, chemical and phase structure of the produced powders were analysed with SEM, TG-DTA, FTIR and XRD. HA-Gel microspheres presented spherical morphology and hollow/core-shell cross-section and included HA nanoparticles and gelatin together according to the SEM, FTIR and XRD studies. TG-DTA results showed that gelatin was evolved from the microspheres ~300 °C, and bare HA was stable up to 1400 °C. Gelatin was released from the microspheres after immersion in the phosphate buffer saline (PBS) solution for 14 days.

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Bu Makaleye Atıf Yap

BAŞTAN, F. E. (2021). PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS. Eskişehir Technical University Journal of Science and Technology A - Applied Sciences and Engineering, Cilt: 22 - Sayı: 1, 10–22. https://ajindex.com/articles/196583

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Kaynakça (13)

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