In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis.
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Temel Bulgular & Veri:Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach.
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Sonuç & Katkı:In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.
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Bu Makaleye Atıf Yap
DURSUN, F., ÖZTÜRK, T. A., GÜVEN, S., KIRMIZIBEKMEZ, H., KARABULUT, G. S., KALIN, S., SÖZERİ, B. (2019). Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report. Journal of Clinical Research in Pediatric Endocrinology, Cilt: 11 - Sayı: 3, 311–318. https://ajindex.com/articles/192782
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