Dergiler / Haydarpaşa Numune Medical Journal / 2019 / Cilt: 59 - Sayı: 4

The Treatment of Lymphangiomas with Bleomycin in Childhood: A Retrospective Observational Study

Sayfa
315–319
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It is an appropriate treatment choice for cases that have previously undergone surgery and then show recurrence or incomplete resection.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Introduction: Lymphangioma is defined as the congenital malformation of the lymphatic system.
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Temel Bulgular & Veri:Methods: Retrospective evaluation was conducted on 20 patients with lymphangioma who were treated with intralesional bleomycin.
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Sonuç & Katkı:It is an appropriate treatment choice for cases that have previously undergone surgery and then show recurrence or incomplete resection.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Introduction: Lymphangioma is defined as the congenital malformation of the lymphatic system. According to morphological classifications, there are macrocystic, microcystic and mix types. Treatments vary from one clinic to another given that there are no commonly accepted guidelines. This study aims to present the results of ultrasonography-guided intralesional bleomycin treatment of lymphangioma. Methods: Retrospective evaluation was conducted on 20 patients with lymphangioma who were treated with intralesional bleomycin. Under local anesthetic and aseptic conditions, 0.4-0.6 mg per kg bodyweight of bleomycin was injected under ultrasonography guidance. The response was graded as “excellent response” (>90% reduction), “good response” (>50% reduction in size) and “poor response” (<50% reduction or no change in size). Results: The 20 cases comprised eleven female and nine male patients with a mean age of 3.1 years. The lymphangioma was located on the neck in eight cases, on the trunk in seven cases, on the axillary region in two cases, the mass extended from the neck to the mediastinum and retropharynx in one case. Also, it was on the anterior surface of the thigh in one case and on the anterior surface of the leg in one patient. Excellent response was seen in 50% of the patients, a good response in 40% and a poor response in one patient. Discussion and Conclusion: Bleomycin injection is very effective for the treatment for macrocystic and mixed type lymphangioma of the neck and on any other surface area of the body. It is an appropriate treatment choice for cases that have previously undergone surgery and then show recurrence or incomplete resection.

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Bu Makaleye Atıf Yap

BİLİCİ, S., AVCİ, V., ÖZTAŞ, T., ASENA, M., ÇELİK, K. (2019). The Treatment of Lymphangiomas with Bleomycin in Childhood: A Retrospective Observational Study. Haydarpaşa Numune Medical Journal, Cilt: 59 - Sayı: 4, 315–319. https://ajindex.com/articles/192469

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Kaynakça (5)

  1. Kulungowski A, Fishman S. Vascular Anomalies. In: Coran AG, Adzick NS, Krummel TM, Laberge JM, Shamberger RC, Caldamone A, editors. Pediatr Surg. 7th ed. Philadelphia. Saunders Elsevier; 2012. p. 1621–4
  2. Mirza B, Ijaz L, Saleem M, Sharif M, Sheikh A. Cystic hygroma: an overview. J Cutan Aesthet Surg 2010;3:139–44. [CrossRef ] 3. Pan P. Ultrasound guided intralesional bleomycin therapy for cystic lymphangioma in childhood. Int J Contemp Pediatr 2017;4:1496–500. [CrossRef ] 4. Wiegand S, Eivazi B, Barth PJ, von Rautenfeld DB, Folz BJ, Mandic R, et al. Pathogenesis of lymphangiomas. Virchows Arch 2008;453:1–8. [CrossRef ] 5. Chen YN, Chen CP, Lin CJ, Chen SW. Prenatal Ultrasound Evaluation and Outcome of Pregnancy with Fetal Cystic Hygromas and Lymphangiomas. J Med Ultrasound 2017;25:12–5. [CrossRef] 6. Ozeki M, Kanda K, Kawamoto N, Ohnishi H, Fujino A, Hirayama M, et al. Propranolol as an alternative treatment option for pediatric lymphatic malformation. Tohoku J Exp Med 2013;229:61–6. [CrossRef ] 7. Swetman GL, Berk DR, Vasanawala SS, Feinstein JA, Lane AT, Bruckner AL. Sildenafil for Severe Lymphatic Malformations. N Engl J Med 2012;366:384–6. [CrossRef ] 8. Wiegand S, Wichmann G, Dietz A. Treatment of Lymphatic Malformations with the mTOR Inhibitor Sirolimus: A Systematic Review. Lymphat Res Biol 2018;16:330–9. [CrossRef ] 9. Rozman Z, Thambidorai CR, Zaleha AM, Zakaria Z, Zulfiqar MA. Lymphangioma: Is intralesional bleomycin sclerotherapy effective? Biomed Imaging Interv J 2011;7:1–8
  3. Bagrodia N, Defnet AM, Kandel JJ. Management of lymphatic malformations. Curr Opin pediatr 2015;27:356–63. [CrossRef ] 11. Cheng J. Doxycycline sclerotherapy in children with head and neck lymphatic malformations. J Pediatr Surg 2015;50:2143– 6. [CrossRef ] 12. Ogita S, Tsuto T, Tokiwa K, Takahashi T. Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 1987;74:690–1. [CrossRef ] 13. Okada A, Kubota A, Fukuzawa M, Imura K, Kamata S. Injection of bleomycin as a primary therapy of cystic lymphangioma. J Pediatr Surg 1992;27:440–3. [CrossRef ] 14. Erikçi V, Hoşgör M, Yıldız M, Örnek Y, Aksoy N, Okur Ö, et al. Intralesional bleomycin sclerotherapy in childhood lymphangioma. Turk J Pediatr 2013;55:396–400
  4. Jain V, Mohta A, Sengar M, Bansal K, Valvi K. Use of intralesional bleomycin as primary therapy in macrocystic lymphangiomas. Indian J Dermatology Venereol Leprol 2013;79:524–5
  5. Upadhyaya VD, Bhatnagar A, Kumar B