KaydedilenlerDerginizi ekleyin

Dergiler / Epilepsi / 2020 / Cilt: 26 - Sayı: 2

Effects of Levetıracetam Treatment on the Autonomic Nervous System Functions in Epilepsy Patients

Epilepsi Hastalarında Levetirasetam Tedavisinin Otonom Sinir Sistemi Fonksiyonları Üzerine Etkileri

Dilek YILMAZ
BURHANETTİN ÇİĞDEM
Sayfa
81–87
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: This study demonstrated that the use of levetiracetam in monotherapy and polytherapy had no significant effect on the autonomic nervous system functions.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: Sudden unexpected death in epilepsy patients is considered to be the most significant epilepsy-related cause of death, and this is associated especially with uncontrolled generalized tonic-clonic seizures, cardiac arrhythmia, decreased heart rate variability, and the use of anti-epileptic drugs.
📊
Temel Bulgular & Veri:In this study, we aimed to investigate the effects of levetiracetam on the autonomic nervous system by evaluating heart rate variability (HRV) in epilepsy patients using levetiracetam.
💡
Sonuç & Katkı:Conclusion: This study demonstrated that the use of levetiracetam in monotherapy and polytherapy had no significant effect on the autonomic nervous system functions.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Sudden unexpected death in epilepsy patients is considered to be the most significant epilepsy-related cause of death, and this is associated especially with uncontrolled generalized tonic-clonic seizures, cardiac arrhythmia, decreased heart rate variability, and the use of anti-epileptic drugs. In this study, we aimed to investigate the effects of levetiracetam on the autonomic nervous system by evaluating heart rate variability (HRV) in epilepsy patients using levetiracetam. Methods: The patients, in whom levetiracetam was started in monotherapy and polytherapy, were divided into two groups in this study. The first group consisted of 29 patients with newly diagnosed epilepsy, in whom levetiracetam was started, and the second group consisted of 11 patients in whom levetiracetam was added to antiepileptic drug treatment. In patients receiving monotherapy and polytherapy, the HRV values measured before levetiracetam was started and the HRV values measured three months after starting levetiracetam in the same patient groups were compared. HRV was measured by a BVP (blood volume pulse) sensor attached to the finger by performing 10-min recordings using the Nexus/BioTrace+ brand device and with frequency-domain spectral analysis. Results: According to the measurements made before starting the treatment and in the third month of the treatment, no significant difference was obtained between the Total Power (TP), Low-Frequency power (LF), High-Frequency power (HF), Very Low-Frequency power (VLF), and LF/ HF values of 29 patients taking levetiracetam in monotherapy and 11 patients taking levetiracetam in polytherapy. Conclusion: This study demonstrated that the use of levetiracetam in monotherapy and polytherapy had no significant effect on the autonomic nervous system functions.

Abstract

Amaç: Epilepsi hastalarında ani beklenmeyen ölüm epilepsi ile ilişkili en önemli ölüm nedeni olarak düşünülmekte ve bu durum özellikle kontrol altına alınamayan generalize tonik klonik nöbetler, kardiyak aritmi, azalmış kalp hızı değişkenliği ve anti-epileptik ilaçların kullanımı gibi nedenlerle ilişkilendirilmektedir. Biz bu çalışmada levetirasetam kullanan epilepsi hastalarında kalp hızı değişkenliğini (HRV) değerlendirilerek levetirasetamın otonom sinir sistemi üzerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: Monoterapi ve politerapide levetirasetam başlanan hastalar iki gruba ayrıldı. Birinci grup yeni epilepsi tanısı konularak levetirasetam başlanan 29 hasta, ikinci grup ise antiepileptik ilaç tedavisine levetirasetam eklenen 11 hastadan oluşmaktaydı. Monoterapi ve politerapi alan hastalarda levetirasetam başlamadan önce HRV ile aynı hasta gruplarında leveterisetam başlandıktan üç ay sonraki HRV değerlerini karşılaştırıldık. HRV parmağa takılmış bir BVP (blood volume pulse) sensörü ile 10 dakikalık kayıtlar yapılarak NeXus/BioTrace+ marka cihazla frekansa dayalı sistemle elde edilmiştir. Bulgular: Levetirasetamı monoterapide kullanan 29 ve politerapide kullanan 11 hastanın tedaviye başlamadan önce ve tedavinin üçüncü ayında değerlendirilen Toplam Güç (TP), Düşük frekanslı güç (LF), Yüksek frekanslı güç (HF), Çok düşük frekanslı güç (VLF), LF/HF değerleri arasında anlamlı bir fark elde edilememiştir. Sonuç: Çalışmamız, levetirasetamın monoterapide ve politerapide kullanımının otonom sinir sistemi fonksiyonları üzerine önemli herhangi bir etkisi olmadığını göstermiştir

🔖

Bu Makaleye Atıf Yap

YILMAZ, D., ÇİĞDEM, B. (2020). Effects of Levetıracetam Treatment on the Autonomic Nervous System Functions in Epilepsy Patients. Epilepsi, Cilt: 26 - Sayı: 2, 81–87. https://ajindex.com/articles/190248

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Shackleton DP, Westendorp RG, Kasteleijn-Nolst Trenité DG, de Craen AJ, Vandenbroucke JP. Survival of patients with epilepsy: an estimate of the mortality risk. Epilepsia 2002;43(4):445–50
  2. Forsgren L, Hauser WA, Olafsson E, Sander JW, Sillanpää M, Tomson T. Mortality of epilepsy in developed countries: a review. Epilepsia 2005;46 Suppl 11:18–27
  3. Devinsky O. Effects of Seizures on Autonomic and Cardiovascular Function. Epilepsy Curr 2004;4(2):43–6
  4. Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 2008;7(11):1021–31
  5. Jeppesen J, Fuglsang-Frederiksen A, Brugada R, Pedersen B, Rubboli G, Johansen P, et al. Heart rate variability analysis indicates preictal parasympathetic overdrive preceding seizure-induced cardiac dysrhythmias leading to sudden unexpected death in a patient with epilepsy. Epilepsia 2014;55(7):e67–71
  6. Lotufo PA, Valiengo L, Benseñor IM, Brunoni AR. A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs. Epilepsia 2012;53(2):272–82
  7. Myers KA, Sivathamboo S, Perucca P. Heart rate variability measurement in epilepsy: How can we move from research to clinical practice? Epilepsia 2018;59(12):2169–78
  8. Rauscher G, DeGiorgio AC, Miller PR, DeGiorgio CM. Sudden unexpected death in epilepsy associated with progressive deterioration in heart rate variability. Epilepsy Behav 2011;21:103–5
  9. Novak JL, Miller PR, Markovic D, Meymandi SK, DeGiorgio CM. Risk Assessment for Sudden Death in Epilepsy: The SUDEP-7 Inventory. Front Neurol 2015;6:252
  10. Stein PK, Domitrovich PP, Huikuri HV, Kleiger RE; Cast Investigators. Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction. J Cardiovasc Electrophysiol 2005;16(1):13–20
  11. Baysal-Kirac L, Serbest NG, Şahin E, Dede HÖ, Gürses C, Gökyiğit A, et al. Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy. Epilepsy Behav 2017;71(Pt A):60–4
  12. Lamberts RJ, Blom MT, Novy J, Belluzzo M, Seldenrijk A, Penninx BW, et al Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy. J Neurol Neurosurg Psychiatry 2015;86(3):309–13
  13. Hesdorffer DC, Tomson T. Sudden unexpected death in epilepsy. Potential role of antiepileptic drugs. CNS Drugs 2013;27(2):113–9
  14. Takayanagi K, Hisauchi I, Watanabe J, Maekawa Y, Fujito T, Sakai Y, et al