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Dergiler / Klinik Psikiyatri Dergisi / 2020 / Cilt: 23 - Sayı: 1

Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder?

Çocuk ve ergen obsesif kompulsif bozukluk tanılı hastalarda nötrofil lenfosit oranı önemli bir parametre olabilir mi?

Aylin Deniz UZUN
Şermin YALIN SAPMAZ
Burak ÇAKIR
Hasan KANDEMİR
Sayfa
101–105
DOI
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The NLR may be potential inlammation markers for OCD in children.

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Amaç & Hipotez:Objective: The number of studies that suggest the possible role of immune abnormalities in the pathogenesis of obsessive-compulsive disorder(OCD) are increasing.
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Temel Bulgular & Veri:Method: In this study, retrospective records of 32 children and adolescents with OCD were screened, and the NLR, PLR,monocyte lymphocyte ratio (MLR) data obtained from the pre-treatment complete blood count were compared with the same data of the healthy control group with similar characteristics.
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Sonuç & Katkı:The NLR may be potential inlammation markers for OCD in children.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The number of studies that suggest the possible role of immune abnormalities in the pathogenesis of obsessive-compulsive disorder(OCD) are increasing. Our aim here is to determine the relationship between neutrophil lymphocyte ratio(NLR) and children and adolescents with OCD.NLR and platelet lymphocyte ratio(PLR) are new, inexpensive, easily reproducible indicators used for the determination of low grade inflammation. Method: In this study, retrospective records of 32 children and adolescents with OCD were screened, and the NLR, PLR,monocyte lymphocyte ratio (MLR) data obtained from the pre-treatment complete blood count were compared with the same data of the healthy control group with similar characteristics. Results: The NLR was found lower in children and adolescents with OCD compared to the control group; yet PLR and MLR were not significantly different. Discussion: Inflammation might play a role in the etiopahogenesis of OCD. The NLR may be potential inlammation markers for OCD in children.

Abstract

Amaç: Obsesif kompulsif bozukluğun(OKB) patogenezinde immün anormalliklerin olası rolünü öne süren çalışmaların sayısı gün geçtikçe artmaktadır. Buradaki amacımız çocuk ve ergenlerde nötrofil lenfosit oranı (NLO) ile OKB arasındaki ilişkiyi belirlemektir. NLO ve trombosit lenfosit oranı (TLO) düşük dereceli inflamasyonun belirlenmesinde kullanılan yeni, ucuz, kolay tekrarlanabilir göstergelerdir. Yöntem: Bu çalışmada OKB tanılı 32 çocuk ve ergenin retrospektif kayıtları tarandı ve tedavi öncesi tam kan sayımından elde edilen NLO, PLO, MLO verileri; benzer özellikli sağlıklı kontrol grubunun aynı verileriyle karşılaştırıldı. Bulgular: NLO; OKB tanısı olan çocuk ve ergenlerde kontrol grubuna göre düşük bulundu; Ancak TLO ve MLO anlamlı olarak farklı değildi. Sonuç: Enflamasyon OKB'nin etiyopatogenezinde rol oynayabilir. NLO, çocuklarda OKB için potansiyel inlamasyon belirteci olabilir.

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Bu Makaleye Atıf Yap

UZUN, A. D., SAPMAZ, Ş. Y., ÇAKIR, B., KANDEMİR, H. (2020). Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder?. Klinik Psikiyatri Dergisi, Cilt: 23 - Sayı: 1, 101–105. https://ajindex.com/articles/188167

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