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Dergiler / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 4

Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

MEHMET TOKAÇ
SEVTAP AYDIN
GÖKÇE TANER
ALPER BİLAL ÖZKARDEŞ
MİNE YAVUZ TAŞLIPINAR
MEHMET DOĞAN
HALİT ZİYA DÜNDAR
MEHMET KILIÇ
ARİF AHMET BAŞARAN
AYŞE NURŞEN BAŞARAN
Sayfa
857–864
Yayın Tarihi
2015-08-13
DOI
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Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.

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Amaç & Hipotez:Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress.
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Temel Bulgular & Veri:Materials and methods: The animals were randomized into 3 groups.
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Sonuç & Katkı:Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Lycopene · cholestasis · DNA damage

Özet

Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.

Abstract

Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.

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Bu Makaleye Atıf Yap

TOKAÇ, M., AYDIN, S., TANER, G., ÖZKARDEŞ, A. B., TAŞLIPINAR, M. Y., DOĞAN, M., DÜNDAR, H. Z., KILIÇ, M., BAŞARAN, A. A., BAŞARAN, A. N. (2015). Hepatoprotective and antioxidant effects of lycopene in acute cholestasis. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 4, 857–864. https://ajindex.com/articles/186187

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Kaynakça (14)

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