KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Biology / 2011 / Cilt: 35 - Sayı: 6

Bioassay studies of 2'-O-ethylmurrangatin isolated from a medicinal plant, Murraya paniculata

Azizuddin SHAIKH
Muhammad İqbal CHOUDHARY
Sayfa
751–755
Yayın Tarihi
2011-06-01
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2'-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:A secondary metabolite, 2'-O-ethylmurrangatin (1), was isolated from the leaves of a medicinal plant, Murraya paniculata.
📊
Temel Bulgular & Veri:The structure of compound 1 was identified with the help of spectroscopic techniques.
💡
Sonuç & Katkı:Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2'-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Murraya paniculata · Rutaceae · 2'-O-ethylmurrangatin

Özet

A secondary metabolite, 2'-O-ethylmurrangatin (1), was isolated from the leaves of a medicinal plant, Murraya paniculata. The structure of compound 1 was identified with the help of spectroscopic techniques. Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2'-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.

Abstract

A secondary metabolite, 2'-O-ethylmurrangatin (1), was isolated from the leaves of a medicinal plant, Murraya paniculata. The structure of compound 1 was identified with the help of spectroscopic techniques. Compound 1 was screened for its antioxidant, lipoxygenase, prolyl endopeptidase, and respiratory burst inhibitory activities. 2'-O-Ethylmurrangatin (1) was found to have significant activity against lipoxygenase enzyme and moderate respiratory burst inhibitory activity, but no activity against either DPPH radical scavenging assay or prolyl endopeptidase enzyme.

🔖

Bu Makaleye Atıf Yap

SHAIKH, A., CHOUDHARY, M. İ. (2011). Bioassay studies of 2'-O-ethylmurrangatin isolated from a medicinal plant, Murraya paniculata. Turkish Journal of Biology, Cilt: 35 - Sayı: 6, 751–755. https://ajindex.com/articles/182541

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Sastri BN. Th e Wealth of India, Council of Scientifi c and Industrial Research, New Delhi, Vol. 6: 446-448, 1962.
  2. Perry LM, Metzger J. Medicinal Plants of East and Southeast Asia. Th e Massachusetts Institute of Technology Press. Cambridge; 1980. p. 367, Choudhary MI, Azizuddin, Khalid A et al. A new coumarin from Murraya paniculata. Planta Med 68: 81-83, 2002. Richard AL. Th e antioxidants of higher plants. Phytochemistry 27: 969-979, 1988. Floyd RA. DNA-Ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide. Biochem Biophys Res Commun 99: 1209-1215, 1981.
  3. Shi H, Hiramatsu M, Kamatsu M et al. Antioxidant property of Fructus momordicae extract. Biochem Mol Biol Intl 40: 1111- 1121, 1996.
  4. Gross MD, Snowdon D, Snowdon A. Plasma antioxidant concentrations in a population of elderly women: fi ndings from the nun study. Nutrition Research 16: 1881-1890, 1996.
  5. Kim YD, Chen B, Beauregard J et al. 17 beta-Estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias aft er brief ischemia/reperfusion. Circulation 94: 2901-2908, 1996. Land WEM. Mechanisms of action of anti-infl ammatory drugs. Advance Drug Research 14: 147-167, 1985. Steinhilber D. 5-Lipoxygenase: A target for anti-infl ammatory drugs revisited. Curr Med Chem 6: 71-85, 1999.
  6. Nie D, Honn KV. Cyclooxygenase, lipoxygenase and tumor angiogenesis. Cellular and Molecular Life Sciences 59: 799- 807, 2002.
  7. Fan W, Komatsu K, Tezuka Y et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu. Biol Pharm Bull 22: 157-161, 1999.
  8. Szeltner Z, Renner V, Polgar L. Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family. Protein Science 9: 353-360, 2000.
  9. Fujita Y, Uehara F, Morimoto Y et al. Studies on inhibition mechanism of autoxidation by tannins and fl avonoids. Yakugaku Zasshi 108: 129-135, 1998.
  10. Smith RC, Reeves JC, Dage RC et al. Antioxidant properties of 2-imidazolones and 2-imidazolthiones. Biochem Pharmacol 36: 1457-1460, 1987.
  11. Tappel AL. Methods in Enzymology, Academic Press,
  12. New York, Vol. 05: pp. 539, 1962.
  13. Yoshimoto T, Walter R, Suru T. Proline-specifi c endopeptidase from Flavobacterium. Purifi cation and properties. J Biol Chem 255: 4786-4792, 1980.
  14. Tan AS, Berridge VM. Superoxide produced by activated neutrophils effi ciently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple c